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首页> 外文会议>International Conference on Bioinformatics and Biomedical Engineering >Chondrogenic Differentiation of MSCs Induced via Cbfa1 Driven by SOX9 Promoter
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Chondrogenic Differentiation of MSCs Induced via Cbfa1 Driven by SOX9 Promoter

机译：通过SOX9启动子驱动的CBFA1诱导MSCs的软弱化分化

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摘要

The good seed cells were the key component of cartilage tissue engineering. Because of their own advantages, mesenchymal stem cells (MSCs) became a good choice of seed cells in cartilage tissue engineering field. However, how to regulate MSCs to directly differentiate into chondrocytes was one of the difficulties at present. Sox9 and Cbfa1 were two important transcription factors for chondrogenic differentiation of MSCs and played an important role in the cartilage formation. In this study, the eukaryotic expression vector of Cbfa1 driven by Sox9 promoter was constructed and then was transfected into MSCs. The higher capacity of stable transfectants(Cbfa1- MSCs) for chondrogenic differentiation had been identified. As a readily available source of seed cells for cartilage tissue engineering, Cbfa1-MSCs should have broad application prospects.
机译：良好的种子细胞是软骨组织工程的关键组分。由于他们自己的优点，间充质干细胞（MSCs）成为软骨组织工程领域的种子细胞的良好选择。然而，如何调节MSCs直接区分细胞细胞是目前的困难之一。 SOX9和CBFA1是用于MSCs的软骨生分化并在软骨形成中发挥重要作用的两个重要转录因子。在该研究中，构建了由SOX9启动子驱动的CBFA1的真核表达载体，然后将其转染到MSC中。已经鉴定了稳定转染剂（CBFA1-MSCs）的稳定转染剂的容量较高。作为软骨组织工程的易于可获得的种子细胞来源，CBFA1-MSC应该具有广泛的应用前景。

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