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首页> 外文会议>IEEE International Conference on Nano/Micro Engineered and Molecular Systems >Electromagnetically powered electrolytic pump and thermo-responsive valve for drug delivery
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Electromagnetically powered electrolytic pump and thermo-responsive valve for drug delivery

机译：电磁电动泵和热响应阀，用于药物输送

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A novel drug delivery device is presented, implementing an electrolytic pump and a thermo-responsive valve. The device is remotely operated by an AC electromagnetic field (40.5~58.5 mT, 450 kHz) that provides the power for the pump and the valve. It is suitable for long-term therapy applications, which use a solid drug in reservoir (SDR) approach and avoids unwanted drug diffusion. When the electromagnetic field is on, the electrolytic pump drives the drug towards the valve. The valve is made of a magnetic composite consisting of a smart hydrogel: Poly (N-Isopropylacrylamide) (PNIPAm) and iron powder. The heat generated in the iron powder via magnetic losses causes the PNIPAm to shrink, allowing the drug to flow past it. When the electromagnetic field is off, the PNIPAm swells, sealing the outlet. In the meantime, the bubbles generated by electrolysis recombine into water, causing a pressure reduction in the pumping chamber. This draws fresh fluid from outside the pump into the drug reservoir before the valve is fully sealed. The recombination can be accelerated by a platinum (Pt) coated catalytic reformer, allowing more fluid to flow back to the drug reservoir and dissolve the drug. By repeatedly turning on and off the magnetic field, the drug solution can be delivered cyclically.
机译：提出了一种新颖的药物输送装置，其实现了电解泵和热响应阀。该设备通过交流电磁场（40.5〜58.5 mT，450 kHz）进行远程操作，为泵和阀门提供动力。它适用于长期治疗应用，这些应用使用储库中的固体药物（SDR）方法并避免了不必要的药物扩散。当电磁场打开时，电解泵将药物推向阀门。该阀由磁性复合材料制成，该复合材料由智能水凝胶：聚（N-异丙基丙烯酰胺）（PNIPAm）和铁粉组成。铁粉中通过磁损耗产生的热量使PNIPAm收缩，从而使药物流过它。当电磁场关闭时，PNIPAm膨胀，密封出口。同时，由电解产生的气泡重新结合成水，从而导致泵送室内的压力降低。在阀门完全密封之前，这会将新鲜的流体从泵外部抽入药物储存器中。可以通过涂有铂（Pt）的催化重整器来加速重组，使更多的流体流回药物储存器并溶解药物。通过反复打开和关闭磁场，可以循环输送药物溶液。

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