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首页> 外文期刊>Journal of Materials Science >Flexible substrate-based thermo-responsive valve applied in electromagnetically powered drug delivery system
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Flexible substrate-based thermo-responsive valve applied in electromagnetically powered drug delivery system

机译：基于柔性基板的热响应阀，在电磁动力输送系统中施加

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摘要

This paper presents a novel drug delivery system consisting of an electrolytic pump to drive the drug solution and a flexible substrate-based thermo-responsive valve to control the exit port. An electromagnetic field (60mT, 450kHz) is used to wirelessly power both the pump and the valve. The valve model is fabricated out of polydimethylsiloxane, in which a thermo-responsive poly N-isopropylacrylamide hydrogel is filled. This valve can avoid undesired drug diffusion at the outlet of the device over an extended period; it also allows a reverse flow to refill the drug reservoir within a given opening time. This is especially suitable for long-term drug delivery using a solid drug in reservoir approach. When the electromagnetic field is turned on, an electrolytic reaction happens in the actuator which results in an electrolysis-bubble expansion that drives the drug liquid toward the valve. In the meantime, the iron microparticles that are embedded into the PDMS substrate produce heat due to magnetic losses. The heating of the iron powder causes the hydrogel to shrink, resulting in an open valve. When the electromagnetic field is turned off, the bubbles are recombined in the presence of electrolysis catalysts, thereby decreasing the pressure in the actuator. This draws fresh body liquid from outside the device into the drug reservoir to dissolve the remaining solid-form drug before the PNIPAM fully seals the valve. Our experimental results reveal that the system is capable of being repeatedly implemented, and flow is effectively controlled by an external magnetic field strength.
机译：本文介绍了一种新型药物输送系统，由电解泵组成，以驱动药物溶液和柔性基板的热响应阀来控制出口。电磁场（60MT，450kHz）用于无线电动泵和阀门。阀门模型由聚二甲基硅氧烷制成，其中填充热响应性聚N-异丙基丙烯酰胺水凝胶。该阀门可以在延长时段内避免在装置的出口处避免不希望的药物扩散;它还允许反转流动以在给定的时间内重新填充药物储存器。这特别适用于使用储层方法的固体药物的长期药物递送。当电磁场导通时，致动器中发生电解反应，这导致电解 - 气泡膨胀，使药物液体朝向阀门驱动。同时，嵌入PDMS衬底的铁微粒由于磁损失而产生热量。铁粉的加热使水凝胶收缩，导致开放式阀门。当电磁场关闭时，气泡在电解催化剂存在下重新组合，从而降低致动器中的压力。这将新鲜的体液从装置外部吸入药物储存器中，以溶解剩余的固体形式药物，然后在肺脂完全密封阀门之前。我们的实验结果表明，该系统能够反复实施，通过外部磁场强度有效地控制流动。

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  • 来源
    《Journal of Materials Science》 |2019年第4期|共11页
  • 作者

    Yi Ying; Huang Ruining; Li Changping;

  • 作者单位

    King Abdullah Univ Sci &

    Technol KAUST Dept Elect Engn Thuwal Saudi Arabia;

    Harbin Inst Technol Sch Mech Engn &

    Automat Shenzhen Peoples R China;

    Chongqing Univ Posts &

    Telecommun Coll Commun &

    Informat Engn Chongqing Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 工程材料学;
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