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首页> 外文会议>IEEE International Conference on Nano/Micro Engineered and Molecular Systems >Flexible micro sensor for intravascular vulnerable plaque diagnostic with electrical impedance spectroscopy
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Flexible micro sensor for intravascular vulnerable plaque diagnostic with electrical impedance spectroscopy

机译：柔性微传感器，用于通过电阻抗光谱法诊断血管内易损斑块

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Studies have shown emerging evidence that rupture of coronary plaque containing a lipid-rich core with subsequent thrombus formation is the most frequent mechanism by which atherosclerosis leads to the acute ischaemic syndromes of unstable angina, acute myocardial infarction, and often times, sudden cardiac death. However, since the lumen is not significantly blocked in these cases, such “vulnerable” plaques show noncritical stenosis in X-ray angiography and Intravascular Ultrasound (IVUS), tools currently available to diagnose coronary artery disease. The ability to distinguish such rupture-prone vulnerable plaques remains largely lacking. Therefore it is of great clinical interest to find improved diagnostic techniques to identify and localize such rupture-prone plaques. On the other hand, lipid has significantly lower electrical impedance than the rest of the vessel components in certain frequency bands [1]. We show in this paper that electrical impedance spectroscopy (EIS) technique can be useful to effectively distinguish plaques with such lipid cores. We include in this paper the design rationale of a four electrode EIS sensor and the measurement results between 1 Hz to 300 KHz of ex-vivo mouse aortas with plaque lesions. The impedance modulus over 200 Hz-100 KHz show consistent elevated values 2-5 times higher than their proximity control sites in all three individual mice. The promising ex-vivo EIS results show promising potential for a reliable unstable plaque diagnostic tool for in-vivo catheter integrated intravascular micro EIS sensors.
机译：研究表明，新兴证据表明，含有富含脂质的核心的冠状动脉斑块破裂并随后形成血栓是动脉粥样硬化导致不稳定型心绞痛，急性心肌梗塞甚至常常是心源性猝死的急性缺血综合征的最常见机制。但是，由于在这些情况下管腔未受到明显阻塞，因此此类“易损”斑块在X射线血管造影和血管内超声（IVUS）（目前可用于诊断冠状动脉疾病的工具）中显示出非严重狭窄。仍然很缺乏区分这种容易破裂的易损斑块的能力。因此，寻找改进的诊断技术以鉴定和定位这种易破裂斑块具有重大的临床意义。另一方面，在某些频带中，脂质的电阻抗明显低于其余的血管成分[1]。我们在本文中表明，电阻抗光谱（EIS）技术可用于有效区分具有此类脂质核心的噬菌斑。我们在本文中包括四电极EIS传感器的设计原理以及离体小鼠主动脉斑块病变在1 Hz至300 KHz之间的测量结果。在所有三只小鼠中，超过200 Hz-100 KHz的阻抗模量显示出持续稳定的升高值，比其邻近控制位点高2-5倍。有希望的离体EIS结果显示了用于体内导管集成的血管内微型EIS传感器的可靠不稳定斑块诊断工具的潜在潜力。

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