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Mathematical model of glucose-insulin metabolism from carbohydrates in type 1 diabetes during postprandial and postabsorptive states

机译:糖尿病1型糖尿病糖尿病葡萄糖 - 胰岛素代谢的数学模型

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In this paper, we propose an extension to our previously developed mathematical model of glucose-insulin metabolism in type 1 diabetes (T1D). It comprises a carbohydrate metabolism subsystem with a solid foundation of the relative impact of carbohydrates on blood glucose levels; an exogenous insulin subsystem that considers the effect of sub-cutaneous and intravenous rapid-acting insulin; and a glucose-insulin metabolism subsystem in T1D for postprandial and postabsorptive states. Simulations of blood glucose excursion in our model during both states demonstrate the reliability and accuracy of our model.
机译:在本文中,我们提出了我们以前开发了1型糖尿病(T1D)的葡萄糖 - 胰岛素代谢的数学模型的延伸。它包括碳水化合物代谢子系统,具有坚实的碳水化合物对血糖水平影响的基础;外源性胰岛素子系统,其考虑亚皮肤和静脉内快速胰岛素的效果;和T1D的葡萄糖 - 胰岛素代谢子系统,用于餐后和清醒状态。两国模型中血糖偏移的仿真展示了我们模型的可靠性和准确性。

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