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首页> 外文会议>International Conference on Photonics, Optics and Laser Technology >Spectral and lifetime measurements of the endogenous fluorescence variation of freshly resected human samples over time: Measuring endogenous fluorescence changes at different moment after tumor or epileptic cortex excision
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Spectral and lifetime measurements of the endogenous fluorescence variation of freshly resected human samples over time: Measuring endogenous fluorescence changes at different moment after tumor or epileptic cortex excision

机译：随时间变化的新鲜切除人类样品的内源性荧光变化的光谱和寿命测量：测量肿瘤或癫痫皮层切除后不同时刻的内源性荧光变化

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摘要

Analysis of human tissue endogenous fluorescence is becoming a new modality of medical imaging. Its capacities represent the missing link between macroscopic radiological tools such as MRI and CT-scan and the surgeon view during surgical procedures. However, numerous aspects of this signal are not well known. Time dependence is one of these aspects. The aim of this work is to investigate the autofluorescence changes with time. Five ex vivo human samples were studied. Spectral and lifetime measurements were acquired each hour. Fluorescence intensity decreased slightly with time. This decrease existed for healthy and tumoral samples and did not affect the differences between them: higher fluorescence intensity for control samples compared to tumor samples. Lifetime values showed a slight decrease too for both type of tissue. This work is the first report of fresh human brain samples multimodal autofluorescence analysis with time.
机译：人体组织内源性荧光的分析正成为医学成像的新形式。它的功能代表了在诸如MRI和CT扫描等宏观放射学工具与外科手术过程中外科医生视图之间缺少的联系。然而，该信号的许多方面不是众所周知的。时间依赖性是这些方面之一。这项工作的目的是研究自体荧光随时间的变化。研究了五个离体人类样品。每小时进行一次光谱和寿命测量。荧光强度随时间略有下降。对于健康和肿瘤样品，这种降低存在，并且不影响它们之间的差异：与肿瘤样品相比，对照样品的荧光强度更高。对于两种类型的组织，寿命值也显示出轻微的降低。这项工作是新鲜的人脑样品随时间进行多峰自发荧光分析的第一份报告。

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