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首页> 外文会议>International Congress on Image and Signal Processing, BioMedical Engineering and Informatics >Complement Factor D (CFD) bound by Saikosaponin D (SSD) extracted from Bupleuri Radix might drive the anti-depression network to function
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Complement Factor D (CFD) bound by Saikosaponin D (SSD) extracted from Bupleuri Radix might drive the anti-depression network to function

机译：从柴胡中提取的Saikosaponin D（SSD）结合的补体因子D（CFD）可能会驱动抗抑郁网络发挥作用

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摘要

Bupleuri Radix, a famous Chinese herbal medicine called Chai-Hu, has been widely used to treat depression like syndromes over a long history. Although associated clinical evidences has been accumulated and studied, its molecule level therapeutic mechanism is still obscure which blocks the understanding and new drug discovery against major depression. In this study, focused on the active compounds extracted from Bupleuri Radix reported with anti-depression effects, target proteins were determined. Following these targeted proteins, protein-protein regulating network towards proteins participated in the anti-depression processes e.g. serotonin secretion and positive regulation of dopamine secretion was constructed. As a result, together with other 12 regulated proteins, targeted protein of Complement Factor D (CFD) which is bound with Saikosaponin D (SSD) was recognized as a candidate biomarker driving the anti-depression network to function. The primary results were also validated with bioinformatics tools (e.g. DAVID and PANTHER) and PubMed collected literatures.
机译：柴胡（Bupleuri Radix）是一种著名的中草药柴胡（Chai-Hu），在很长的历史上已被广泛用于治疗抑郁症等综合症。尽管已经积累和研究了相关的临床证据，但其分子水平的治疗机制仍不清楚，这阻碍了对重度抑郁症的理解和新药的发现。在这项研究中，集中于从Bupleuri Radix提取的具有抗抑郁作用的活性化合物中，确定了目标蛋白。继这些靶向蛋白质之后，针对蛋白质的蛋白质-蛋白质调节网络参与了抗抑郁过程，例如：建立了5-羟色胺分泌和多巴胺分泌的正调控。结果，与Saikosaponin D（SSD）结合的补体因子D（CFD）的靶向蛋白与其他12种调节蛋白一起被认为是驱动抗抑郁网络发挥作用的候选生物标志物。主要结果还通过生物信息学工具（例如DAVID和PANTHER）和PubMed收集的文献进行了验证。

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