首页>外文期刊>医学、药学、卫生>药学>Xenobiotica: the fate of foreign compounds in biological systems

Xenobiotica: the fate of foreign compounds in biological systems

Xenobiotica: the fate of foreign compounds in biological systems

SCIMEDLINECA

中文名称：Xenobiotica：生物系统中外来化合物的命运

ISSN：0049-8254
出版周期：-

发文量：1660

期刊论文

年度选择

2022
- 第12期
2021
- 第12期
2020
- 第12期
2019
- 第6期
- 第12期
2018
- 第12期
2017
- 第12期
2016
- 第12期
2015
- 第12期
2014
- 第12期
2013
- 第1期
- 第2期
- 第3期
- 第4期
- 第5期
- 第6期
- 第7期
- 第8期
- 第9期
- 第10期
- 第11期
- 第12期
2012
- 第1期
- 第2期
- 第3期
- 第4期
- 第5期
- 第6期
- 第7期
- 第8期
- 第9期
- 第10期
- 第11期
- 第12期
2011
- 第1期
- 第2期
- 第3期
- 第4期
- 第5期
- 第6期
- 第7期
- 第8期
- 第9期
- 第10期
- 第11期
- 第12期
2010
- 第1期
- 第2期
- 第3期
- 第4期
- 第5期
- 第6期
- 第7期
- 第8期
- 第9期
- 第10期
- 第11期
- 第12期
2009
- 第1期
- 第2期
- 第3期
- 第4期
- 第5期
- 第6期
- 第7期
- 第8期
- 第9期
- 第10期
- 第11期
- 第12期
2008
- 第1期
- 第2期
- 第3期
- 第4期
- 第5期
- 第6期
- 第8期
- 第9期
- 第10期
- 第11期
- 第12期
2007
- 第1期
- 第2期
- 第3期
- 第4期
- 第5期
- 第6期
- 第7期
- 第8期
- 第9期
- 第11期
- 第12期
2006
- 第1期
- 第3期
- 第4期
- 第5期
- 第6期
- 第7期
- 第8期
- 第9期
- 第11期
- 第12期
2005
- 第1期
- 第2期
- 第3期
- 第4期
- 第5期
- 第6期
- 第7期
- 第8期
- 第9期
- 第11期
- 第12期
2004
- 第1期
- 第2期
- 第3期
- 第4期
- 第5期
- 第6期
- 第7期
- 第8期
- 第9期
- 第10期
- 第12期
2003
- 第1期
- 第2期
- 第3期
- 第4期
- 第5期
- 第6期
- 第7期
- 第8期
- 第9期
- 第10期
- 第11期
- 第12期
2002
- 第1期
- 第2期
- 第3期
- 第4期
- 第5期
- 第6期
- 第7期
- 第8期
- 第9期
- 第10期
- 第11期
- 第12期
2001
- 第1期
- 第2期
- 第3期
- 第4期
- 第5期
- 第6期
- 第7期
- 第9期
- 第10期
- 第11期
- 第12期
2000
- 第1期
- 第2期
- 第3期
- 第4期
- 第7期
- 第8期
- 第9期
- 第10期
- 第11期
- 第12期
1999
- 第1期
- 第2期
- 第3期
- 第4期
- 第5期
- 第6期
- 第7期
- 第8期
- 第9期
- 第10期
- 第11期
- 第12期
1998
- 第1期
- 第2期
- 第3期
- 第4期
- 第5期
- 第6期
- 第7期
- 第8期
- 第9期
- 第10期
- 第11期
- 第12期

更多>>

全选（0）

1.Use of cultured precision-cut rat lung slices to study the in vitro induction of pulmonary cytochrome P450 forms.

机译：使用培养的精确切割的大鼠肺切片研究体外诱导的肺细胞色素P450形式。
- 作者：Lake BG;Meredith C;Scott MP;Renwick AB;Price RJ
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第7期
- Lung;
- g lt;
- 3gt;
- 肺;
2.Metabolism of methyl-(E)-2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacry late (azoxystrobin) in rat.

机译：大鼠甲基-（E）-2-（2-（6-（6-（2-氰基苯氧基）嘧啶-4-基氧基）苯基）-3-甲氧基丙烯酸（azoxystrobin）的代谢。
- 作者：Laird WJ;Gledhill AJ;Lappin GJ
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第6期
- ICIA 5504;
- Oral;
- Unmarried;
3.Actions of quercetin on gluconeogenesis and glycolysis in rat liver.

机译：槲皮素对大鼠肝脏糖异生和糖酵解的作用。
- 作者：Gasparin FR;Spitzner FL;Ishii Iwamoto EL;Bracht A;Constantin J
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第9期
- Gluconeogenesis;
- Glycolysis;
- Liver;
- Quercetin;
- 糖原异生;
- 糖原酵解;
- 肝;
- 槲皮素;
4.Pharmacokinetics, metabolism and excretion of an inhibitor of inducible nitric oxide synthase, L-NIL-TA, in dog.

机译：诱导型一氧化氮合酶L-NIL-TA抑制剂在犬体内的药代动力学，代谢和排泄。
- 作者：Zhang JY;Wang YF;Milton MN;Beconi M;Chang M;Yin D;Breau AP;Paulson SK
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第11期
- Amides;
- Enzyme Inhibitors;
- Nitric-Oxide Synthase;
- Tetrazoles;
- 酰胺类;
- 酶抑制剂;
- 一氧化氮合酶;
- 四唑类;
5.4-Biphenylaldehyde and 9-anthraldehyde: two fluorescent substrates for determining P450 enzyme activities in rat and human.

机译：4-联苯醛和9-乙醛：用于确定大鼠和人体内P450酶活性的两种荧光底物。
- 作者：Marini S;Grasso E;Longo V;Puccini P;Riccardi B;Gervasi PG
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第1期
- Aldehydes;
- Anthracenes;
- Biphenyl Compounds;
- Cytochrome P 450 Enzyme System metabolism;
- 醛类;
- 蒽类;
- 联苯化合物;
- 荧光染料;
6.Comparative metabolism of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat and dog.

机译：大鼠和狗中2,4-二氯苯氧基乙酸（2,4-D）的新陈代谢比较。
- 作者：van Ravenzwaay B;Hardwick TD;Needham D;Pethen S;Lappin GJ
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第8期
- 2;
- 4-Dichlorophenoxyacetic Acid;
- Herbicides;
- 2;
- 4-二氯苯氧乙酸;
- 除莠剂;
7.Antioxidant and free radical scavenging activity of isoflavone metabolites.

机译：异黄酮代谢物的抗氧化和自由基清除活性。
- 作者：Rimbach G;De Pascual Teresa S;Ewins BA;Matsugo S;Uchida Y;Minihane AM;Turner R;VafeiAdou K;Weinberg PD
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第9期
- Antioxidants;
- Free Radical Scavengers;
- Isoflavones;
- Soybeans;
- 抗氧化药;
- 自由基清除剂;
- 异黄酮类;
- 黄豆;
8.Inhibitory effect of troleandomycin on the metabolism of omeprazole is CYP2C19 genotype-dependent.

机译：曲安霉素对奥美拉唑代谢的抑制作用是CYP2C19基因型依赖性的。
- 作者：He N;Huang SL;Zhu RH;Tan ZR;Liu J;Zhu B;Zhou HH
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第2期
- Anti-Bacterial Agents;
- Anti-Ulcer Agents;
- Aryl Hydrocarbon Hydroxylases;
- 抗溃疡病药;
- 芳基烃羟化酶类;
- 奥美拉唑;
- 醋竹桃霉素;
9.mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates.

机译：狗肝细胞色素P450的mRNA和蛋白表达与人CYP2C底物的代谢有关。
- 作者：Graham MJ;Bell AR;Crewe HK;Moorcraft CL;Walker L;Whittaker EF;Lennard MS
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第3期
- Cytochrome P-450 Enzyme System;
- Dextromethorphan;
- Liver;
- Mephenytoin;
- Proteins;
- 右美沙芬;
- 肝;
- 美芬妥英;
- 蛋白质类;
- RNA;
- 信使;
- 华法林;
10.Characterization of bropirimine O-glucuronidation in human liver microsomes.

机译：人肝微粒体中溴嘧啶O-葡萄糖醛酸化的表征。
- 作者：Wynalda MA;Wynalda KM;Amore BM;Fagerness PE;Wienkers LC
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第10期
- Cytosine;
- Glucuronidase;
- Microsomes;
- Liver;
- 胞嘧啶;
- 葡糖醛酸酶;
- 微粒体;
- 肝;
11.Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes.

机译：细胞色素P450酶和UDP-葡萄糖醛酸转移酶在大鼠翻囊和肠微粒体中的药物代谢的催化活性。
- 作者：Takemoto K;Yamazaki H;Tanaka Y;Nakajima M;Yokoi T
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第1期
- Microsomes;
- Intestines;
- Small;
- enzymology;
- drug metabolism;
- 微粒体;
12.Transcriptional regulation of cytochrome P4503A4 gene expression: effects of inherited mutations in the 5'-flanking region.

机译：细胞色素P4503A4基因表达的转录调控：5'侧翼区遗传突变的影响。
- 作者：Hamzeiy H;Bombail V;Plant N;Gibson G;Goldfarb P
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第11期
- 5' Flanking Region;
- Cytochrome P-450 Enzyme System;
- Gene Expression Regulation;
- Enzymologic;
- 基因表达调控;
- 酶学;
- 突变;
13.Hepatotoxicity of ketoconazole in Sprague-Dawley rats: glutathione depletion, flavin-containing monooxygenases-mediated bioactivation and hepatic covalent binding.

机译：酮康唑对Sprague-Dawley大鼠的肝毒性：谷胱甘肽耗竭，含黄素的单加氧酶介导的生物激活和肝共价结合。
- 作者：Rodriguez RJ;Buckholz CJ
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第4期
- binding;
- Hepatotoxicity;
- NOS;
- Proteins;
- 蛋白质类;
14.Absorption, distribution, metabolism and excretion of telmesteine, a mucolitic agent, in rat.

机译：端粒斯坦（粘液剂）在大鼠中的吸收，分布，代谢和排泄。
- 作者：Lee J;Son J;Rhee SW;Kim DH
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第7期
- Radioactivity;
- telmesteine;
- Rattus norvegicus;
- Carbon ion;
- Oral;
- 放射性;
15.Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices.

机译：使用精确切割的大鼠肝切片在体内和体外诱导大鼠肝CYP1A，CYP2B，CYP3A和CYP4A亚家族形成mRNA的研究。
- 作者：Meredith C;Scott MP;Renwick AB;Price RJ;Lake BG
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第5期
- RNA;
- Messenger;
- Cytochrome P-450 CYP2B1;
- RNA;
- 信使;
- 细胞色素P-450 CYP2B1;
16.Pharmacokinetics and tissue distribution of the nonadecapeptide Moli1901 in rats and mice.

机译：大鼠和小鼠中非肽Moli1901的药代动力学和组织分布。
- 作者：McNulty MJ;Hutabarat RH;Findlay JW;Devereux K;Knick VC;Harvey RJ;Molina L
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第2期
- Anti-Bacterial Agents;
- Peptides;
- Cyclic;
- 肽类;
- 环;
17.Verapamil: identification of novel metabolites in cultures of primary human hepatocytes and human urine by LC-MS(n) and LC-NMR.

机译：维拉帕米（Verapamil）：通过LC-MS（n）和LC-NMR鉴定原代人肝细胞和人尿培养物中的新代谢产物。
- 作者：Borlak J;Walles M;Elend M;Thum T;Preiss A;Levsen K
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2003年第6期
- Human;
- Verapamil;
- Phase;
- Morphine Sulfate;
- 维拉帕米;
18.Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes.

机译：普仑司特和扎鲁司特具有抑制人肝细胞色素P450酶的潜力。
- 作者：Liu KH;Lee YM;Shon JH;Kim MJ;Lee SS;Yoon YR;Cha IJ;Shin JG
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2004年第5期
- zafirlukast;
- pranlukast;
- CYP2C9;
- Psychological inhibition;
- Tolbutamide;
- 甲苯磺丁脲;
19.Apparent absolute oral bioavailability in excess of 100% for a vitronectin receptor antagonist (SB-265123) in rat. II. Studies implicating transporter-mediated intestinal secretion.

机译：大鼠玻连蛋白受体拮抗剂（SB-265123）的表观绝对口服生物利用度超过100％。二。涉及转运蛋白介导的肠道分泌的研究。
- 作者：Ward KW;Hardy LB;Kehler JR;Azzarano LM;Smith BR
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2004年第4期
- SB 265123;
- Membrane Transport Proteins;
- Oral;
- Biological Availability;
- receptor;
- 生物利用度;
20.Biotransformation of chlorpyrifos and diazinon by human liver microsomes and recombinant human cytochrome P450s (CYP).

机译：人肝微粒体和重组人细胞色素P450（CYP）对毒死rif和二嗪农的生物转化。
- 作者：Sams C;Cocker J;Lennard MS
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2004年第10期
- Chlorpyrifos;
- Cytochrome P-450 Enzyme System;
- Diazinon;
- Microsomes;
- Liver;
- 毒死蜱;
- 二嗪农;
- 微粒体;
- 肝;
21.Stereoselective glucuronidation and hydroxylation of etodolac by UGT1A9 and CYP2C9 in man.

机译：UGT1A9和CYP2C9对人的依托度酸的立体选择性葡萄糖醛酸化和羟化作用。
- 作者：Tougou K;Gotou H;Ohno Y;Nakamura A
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2004年第5期
- Etodolac;
- CYP2C9;
- Hydroxylation;
- 依托度酸;
- 羟基化;
22.Oxidative one-carbon cleavage of the octyl side chain of olanexidine, a novel antimicrobial agent, in dog liver microsomes.

机译：狗肝微粒体中一种新型抗菌剂olanexidine的辛基侧链的氧化一碳裂解。
- 作者：Umehara K;Shimokawa Y;Koga T;Ohtani T;Miyamoto G
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2004年第1期
- Carbon ion;
- Dermatomyositis;
- Cytokinesis;
- 1-(3;
- 4-dichlorobenzyl)-5-octylbiguanide;
- 皮肌炎;
23.Activity-based exposure comparisons among humans and nonclinical safety testing species in an extensively metabolized drug candidate

机译：在广泛代谢的候选药物中人类和非临床安全性检测物种之间基于活动的暴露比较
- 作者：ZhuX.;SlatterJ.G.;EmeryM.G.;DeaneM.R.;AkramiA.;ZhangX.;HickmanD.;SkilesG.L.;SubramanianR.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第7期
- 11β-HSD1 inhibitor;
- Active circulating metabolites;
- AMG 221;
- Clinical candidate;
- MIST;
- Plasma metabolites;
- Safety testing of metabolites;
24.Disposition and metabolism of [14C]PTZ601 in healthy volunteers

机译：[14C] PTZ601在健康志愿者中的处置和代谢
- 作者：FlarakosJ.;TingL.S.L.;DuY.;SteinD.S.;ReynoldsC.V.;PatelM.;RoyS.;MangoldJ.B.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第3期
- Carbapenems;
- Human disposition and metabolism;
- Mass balance;
- Radiolabeled PTZ601;
25.In vitro models of xenobiotic metabolism in trout for use in environmental bioaccumulation studies

机译：用于环境生物富集研究的鳟鱼异生物代谢的体外模型
- 作者：UcheaC.;SardaS.;Schulz-UtermoehlT.;OwenS.;ChipmanK.J.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第5期
- Biotransformation;
- Spheroids;
- Trout hepatocytes;
- Trout liver S9;
26.Hormonal regulation of Cyp4a isoforms in mouse liver and kidney

机译：小鼠肝脏和肾脏中Cyp4a亚型的激素调控
- 作者：ZhangY.;KlaassenC.D.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第12期
- Cyp4a;
- Growth hormone;
- Sex hormone;
27.Pharmacokinetic characterization of the novel TAZ modulator TM-25659 using a multicompartment kinetic model in rats and a possibility of its drug-drug interactions in humans

机译：在大鼠中使用多室动力学模型对新型TAZ调节剂TM-25659进行药代动力学表征及其在人体内的药物相互作用
- 作者：LeeK.-R.;ChoiS.H.;SongJ.-S.;KwakE.-Y.;ChaeY.-J.;ImS.H.;LeeB.H.;SeoH.;ChoW.-K.;KimM.-S.;KimN.J.;AhnS.-H.;BaeM.A.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第2期
- Modeling;
- Nonlinear kinetics;
- Pharmacokinetics;
- TAZ;
- TM-25659;
28.A phase I, open-label, single-dose, mass balance study of 14C-labeled abiraterone acetate in healthy male subjects.

机译：在健康男性受试者中进行14C标记的醋酸阿比特龙酯的I期，开放标签，单剂量，质量平衡研究。
- 作者：Milin Acharya;Martha Gonzalez;Geert Mannens;Ronald De Vries;Christian Lopez;Thomas Griffin;NamPhuong Tran
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第4期
29.Effects of OCT2 c.602C > T genetic variant on the pharmacokinetics of lamivudine

机译：OCT2 c.602C> T基因变异对拉米夫定药代动力学的影响
- 作者：ChoiC.-I.;BaeJ.-W.;KeumS.-K.;LeeY.-J.;LeeH.-I.;JangC.-G.;LeeS.-Y.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第7期
- Genetic polymorphism;
- Lamivudine;
- OCT2;
- Pharmacogenomics;
- Pharmacokinetics;
30.Precision cut lung slices as an efficient tool for in vitro lung physio-pharmacotoxicology studies

机译：精密切割的肺片可作为体外肺生理-药物毒理学研究的有效工具
- 作者：MorinJ.-P.;BasteJ.-M.;GayA.;CrochemoreC.;CorbièreC.;MonteilC.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第1期
- Air-liquid interface;
- Airway reactivity;
- Biomechanics;
- Complex aerosols;
- Dynamic organ culture;
- Lung slices;
- Toxicology;
- Vascular reactivity;
- Xenobiotic metabolism;
31.Identification of the metabolites of lesogaberan using linear trap quadrupole orbitrap mass spectrometry and hydrophilic interaction liquid chromatography

机译：线性阱四极杆Orbitrap质谱和亲水作用液相色谱法鉴定来沙加伯兰的代谢产物
- 作者：EkdahlA.;Aurell-HolmbergA.;CastagnoliJr.N.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第5期
- Drug evaluation;
- Gastroesophageal reflux;
- Mass spectrometry;
- Metabolites;
- Preclinical;
32.Structure-based investigation of rat aldehyde oxidase inhibition by flavonoids

机译：黄酮类化合物对大鼠醛氧化酶的基于结构的研究
- 作者：Hamzeh-MivehroudM.;RahmaniS.;RashidiM.-R.;HosseinpourFeiziM.-A.;DastmalchiS.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第8期
- Docking;
- Enzyme inhibition assay;
- Molecular modeling;
- Quantitative structure-activity relationship;
33.Metabolism of 2,2′,3,3′,6,6′-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent

机译：苯巴比妥或地塞米松诱导的大鼠组织切片中2,2'，3,3'，6,6'-六氯联苯（PCB 136）阻转异构体的代谢与性别有关
- 作者：WuX.;Kania-KorwelI.;ChenH.;StamouM.;DammanahalliK.J.;DuffelM.;LeinP.J.;LehmlerH.-J.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第11期
- Atropisomeric enrichment;
- Cytochrome P450 enzymes;
- Sex differences;
34.The volume of distribution is an indicator of poor in vitro-in vivo extrapolation of clearance for acidic drugs in the rat

机译：分布的体积表明大鼠体内酸性药物清除率的体内外推算能力较差
- 作者：Sohlenius-SternbeckA.-K.;FagerholmU.;BylundJ.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第8期
- Acids;
- CLint;
- Hepatocytes;
- in vitro to in vivo scaling;
- Liver;
- Metabolism;
- Regression offset;
- Volume of distribution;
35.Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus

机译：麦考酚酸葡糖醛酸苷通过多药耐药相关蛋白2转运，而这种转运不受环孢霉素，他克莫司或西罗莫司的抑制
- 作者：PatelC.G.;OgasawaraK.;AkhlaghiF.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第3期
- AcMPAG;
- Drug interactions;
- Immunosuppressive agents;
- MDCK-MRP2;
- MPA;
- MPAG;
- Pharmacokinetics;
- Translocation;
36.Evaluation of transporter-mediated hepatic uptake in a non-radioactive high-throughput assay: A study of kinetics, species difference and plasma protein effect

机译：在非放射性高通量测定中评估转运蛋白介导的肝摄取：动力学，物种差异和血浆蛋白效应的研究
- 作者：LiL.;NouraldeenA.;WilsonA.G.E.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第3期
- Active transporters;
- Hepatic uptake;
- High throughput;
- Kinetics;
37.Elucidation of the mechanism of ribose conjugation in a pyrazole-containing compound in rodent liver

机译：阐明啮齿类动物肝脏中含吡唑化合物中核糖结合的机理
- 作者：LeH.;FordK.A.;KhojastehS.C.;FanP.W.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第3期
- ADP conjugation;
- ADP-ribosyltransferase;
- NADase;
- Phase II metabolism;
- Phosphatase;
- Pyrazole;
- Ribosylation;
38.Bioavailability, metabolism and disposition of oral pazopanib in patients with advanced cancer

机译：晚期癌症患者口服帕唑帕尼的生物利用度，代谢和处置
- 作者：DengY.;SychterzC.;SuttleA.B.;DarM.M.;BershasD.;NegashK.;QianY.;ChenE.P.;GoryckiP.D.;HoM.Y.K.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第5期
- Absorption;
- Bioavailability;
- Excretion;
- Human;
- Metabolism;
- Pazopanib;
- Pharmacokinetics;
39.Interspecies variation in the metabolism of zoniporide by aldehyde oxidase

机译：醛氧化酶作用于Zoniporide的种间差异
- 作者：DalvieD.;XiangC.;KangP.;ZhouS.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第5期
- Aldehyde oxidase;
- Species differences;
- Zoniporide;
40.Cryopreservation of precision-cut tissue slices

机译：精密切割组织切片的冷冻保存
- 作者：FahyG.M.;GuanN.;DeGraafI.A.M.;TanY.;GriffinL.;GroothuisG.M.M.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第1期
- Chilling injury;
- Cooling rate;
- Fracturing;
- Osmotic stress;
- Thermal shock;
- Tissue banking;
- Viability assays;
- Warming rate;
41.A novel matrix for the short-term storage of cells: Utility in drug metabolism and drug transporter studies with rat, dog and human hepatocytes

机译：一种新型的细胞短期储存基质：可用于大鼠，犬和人肝细胞的药物代谢和药物转运研究
- 作者：PalmgrenA.-P.;FihnB.-M.;BirdJ.;CourtneyP.;GrimeK.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第6期
- Dog;
- Enzyme activity;
- Fresh Hepatocytes;
- Human;
- Rat;
- Storage;
- Transporter activity;
42.Assessment of immunotoxicity using precision-cut tissue slices

机译：使用精密切割的组织切片评估免疫毒性
- 作者：SewaldK.;BraunA.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第1期
- Allergy;
- Contact sensitizer;
- Hypersensitivity;
- Immunosuppression;
- Inflammation;
- Lipopolysaccharide;
- Precision-cut lung slices;
- Respiratory sensitizer;
43.Effects of single or repeated silymarin administration on pharmacokinetics of risperidone and its major metabolite, 9-hydroxyrisperidone in rats

机译：水飞蓟素单次或重复给药对利培酮及其主要代谢产物9-羟基利培酮的药代动力学的影响
- 作者：LeeH.J.;LeeK.S.;ChaeS.W.;ParkJ.H.;ChoiJ.M.;RhieS.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第3期
- 9-hydroxyrisperidone;
- Bioavailability;
- Drug interactions;
- P-glycoprotein;
- Risperidone;
- Silymarin;
44.Cooperative effects for CYP2E1 differ between styrene and its metabolites

机译：CYP2E1的协同作用在苯乙烯及其代谢物之间有所不同
- 作者：HartmanJ.H.;BoysenG.;MillerG.P.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第9期
- Allostery;
- Cooperativity;
- CYP2E1;
- Inhibition;
- P450 2E1;
- Styrene;
45.Absorption, distribution, metabolism and excretion of the novel SARM GTx-024 [(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy- 2-methylpropanamide] in rats

机译：新型SARM GTx-024 [（S）-N-（4-氰基-3-（三氟甲基）苯基）-3-（4-氰基苯氧基）-2-羟基-2-甲基丙酰胺的吸收，分布，代谢和排泄在大鼠中
- 作者：KimJ.;WangR.;VeverkaK.A.;DaltonJ.T.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第11期
- Mass balance;
- Pharmacokinetics;
- Quantitative whole-body autoradiography;
46.A high throughput assay for the glucuronidation of 7-hydroxy-4- trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes

机译：重组人UDP-葡萄糖醛酸转移酶和肝微粒体对7-羟基-4-三氟甲基香豆素进行葡萄糖醛酸化的高通量检测
- 作者：RahikainenT.;H?kkinenM.R.;FinelM.;PasanenM.;JuvonenR.O.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第10期
- Conjugation;
- Drug metabolism;
- Enzyme;
- Fluorescence assay;
- Michaelis - Menten;
47.A simplified approach to predict CYP3A-mediated drug-drug interactions at early drug discovery: Validation with clinical data

机译：在早期药物发现时预测CYP3A介导的药物相互作用的一种简化方法：用临床数据进行验证
- 作者：RiouxN.;BatongaJ.;ColomboF.;MasséJ.;ZoukiC.;RibadeneiraM.D.;DuanJ.;BethellR.C.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第7期
- CYP3A inhibition;
- Drug-drug interaction;
- Human;
48.Development of a live tissue microtome: Reflections of an amateur machinist

机译：活组织切片机的开发：一位业余机械师的思考
- 作者：KrumdieckC.L.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第1期
- Coring tool;
- Krumdieck slicer;
- Tissue slicer;
49.Alteration in plasma protein binding properties of propranolol and flurbiprofen during development of adjuvant-induced arthritis in rats

机译：佐剂诱发的大鼠关节炎过程中普萘洛尔和氟比洛芬血浆蛋白结合特性的变化
- 作者：KawaseA.;IkutaH.;UnoS.;YamamotoK.;AkitsuN.;NagaoT.;IwakiM.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第3期
- Albumin;
- Alpha 1-acid glycoprotein;
- Disease state;
- Inflammation;
50.Cloning and functional characterization of the pig (Sus scrofa) organic anion transporting polypeptide 1a2

机译：猪（Sus scrofa）有机阴离子转运多肽1a2的克隆与功能鉴定
- 作者：YuY.;LiuX.;ZhangZ.;XiaoY.;HongM.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2013年第8期
- Drug transport;
- OATP;
- Pig;
- Transporter protein;
- Uptake activity;
51.Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions

机译：鉴定合适的选择性乙醛氧化酶催化反应抑制剂
- 作者：Nirogi Ramakrishna;Kandikere Vishwottam;Palacharla Raghava Choudary;Bhyrapuneni Gopinadh;Kanamarlapudi Vijaya Bhargava;Ponnamaneni Ranjith Kumar;Manoharan Arun Kumar
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Aldehyde oxidase;
- cytochrome P450;
- drug-drug interaction;
- uncompetitive;
52.Identification of glucuronidation and biliary excretion as the main mechanisms for gossypol clearance: in vivo and in vitro evidence

机译：葡萄糖醛酸化和胆汁排泄作为棉酚清除的主要机制的鉴定：体内和体外证据
- 作者：Liu Hongming;Sun Hua;Lu Danyi;Zhang Yuchen;Zhang Xingwang;Ma Zhiguo;Wu Baojian
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Biliary excretion;
- glucuronidation;
- gossypol;
- UGT;
- UPLC-QTOF/MS;
53.Application of a liquid chromatography-tandem mass spectrometry method to the pharmacokinetics, bioavailability and tissue distribution of neohesperidin dihydrochalcone in rats

机译：液相色谱-串联质谱法在新橙皮苷二氢查耳酮药代动力学，生物利用度和组织分布中的应用
- 作者：Wang Xianqin;Pan Yu;Ma Jianshe;Shi Shaohua;Zheng Xiaoyong;Xiang Zheng
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- LC-MS;
- neohesperidin dihydrochalcone;
- pharmacokinetic;
- tissue distribution;
54.Disposition of fragrance ingredient [C-14]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application

机译：雄性Fisher大鼠中香气成分[C-14] 1-（1,2,3,4,5,6,7,8-八氢-2,3,8,8-四甲基-2-萘基）乙酮的处理口服和皮肤应用
- 作者：Waidyanatha Suramya;Ryan Kristen
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- 1-(1;
- 2;
- 3;
- 4;
- 5;
- 6;
- 7;
- 8-Octahydro-2;
- 3;
- 8;
- 8-tetramethyl-2-naphthalenyl)ethanone;
- biliary excretion;
- dermal absorption;
- enterohepatic recirculation;
- fragrance ingredient;
- oral absorption;
55.Disposition and metabolism of LY2603618, a Chk-1 inhibitor following intravenous administration in patients with advanced and/or metastatic solid tumors

机译：晚期和/或转移性实体瘤患者静脉给药后Chk-1抑制剂LY2603618的处置和代谢
- 作者：Wickremsinhe Enaksha R.;Hynes Scott M.;Palmieri Margo D.;Mitchell Malcolm I.;Abraham Trent L.;Rehmel Jessica Fayer;Chana Emilie;Jost Lorenz M.;Cassidy Kenneth C.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Aldehyde oxidase;
- cancer patients;
- excretion;
- mass balance;
- radiolabelled study;
56.Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications

机译：药物代谢酶和转运蛋白的遗传人源化小鼠模型及其应用
- 作者：Scheer Nico;Wolf C. Roland
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Bioavailability;
- clearance;
- drug-drug interactions;
- drug metabolising enzymes;
- human metabolites;
- transporters;
57.Xenobiotic-urea conjugates; chemical or biological?

机译：异物-尿素结合物;化学的还是生物的？
- 作者：Mitchell Stephen C.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Conjugation;
- Phase II;
- urea;
- ureido radical;
58.The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease

机译：合成的三萜类RTA dh404（CDDO-dhTFEA）在患有慢性肾脏病的大鼠中恢复Nrf2活性并减轻氧化应激，炎症和纤维化
- 作者：Aminzadeh Mohammad A.;Reisman Scott A.;Vaziri Nosratola D.;Khazaeli Mahyar;Yuan Jun;Meyer Colin J.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Keap1;
- NF-kappa B;
- nephrectomy;
- reactive oxygen species;
59.Temporal expression of transporters and receptors in a rat primary co-culture blood-brain barrier model

机译：大鼠原代共培养血脑屏障模型中转运蛋白和受体的时间表达
- 作者：Liu Houfu;Li Yang;Lu Sijie;Wu Yiwen;Sahi Jasminder
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Brain-blood barrier;
- brain microvessel endothelial cells;
- receptors;
- transporters;
60.Optimizing the use of rainbow trout hepatocytes for bioaccumulation assessments with fish

机译：优化使用虹鳟鱼肝细胞进行鱼类生物蓄积评估
- 作者：Fay Kellie A.;Fitzsimmons Patrick N.;Hoffman Alex D.;Nichols John W.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Bioaccumulation assessment;
- hepatocellularity;
- hepatocytes;
- intrinsic clearance;
- in vitro-in vivo extrapolation;
- trout;
61.Pharmacokinetics and disposition of dalcetrapib in rats and monkeys

机译：达西替尼在大鼠和猴子中的药代动力学和处置
- 作者：Takubo Hiroaki;Ishikawa Tomohiro;Kuhlmann Olaf;Nemoto Hiroyuki;Noguchi Tomoyuki;Nanayama Toyomichi;Komura Hiroshi;Kogayu Motohiro
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- CETP;
- covalent binding;
- JTT-705;
- metabolites;
- mixed disulfide;
- RO4607381;
- thioester;
62.Structure identification and elucidation of mosapride metabolites in human urine, feces and plasma by ultra performance liquid chromatography-tandem mass spectrometry method

机译：超高效液相色谱-串联质谱法鉴定和鉴定人尿，粪便和血浆中莫沙必利代谢物的结构
- 作者：Sun Xiaohong;Zhao Longshan;Niu Lili;Qin Feng;Lu Xiumei;Xiong Zhili;Li Famei
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Human;
- metabolism;
- mosapride;
- UPLC-ESI-MS/MS;
63.Effect of commonly used organic solvents on Aldehyde oxidase-mediated Vanillin, Phthalazine and Methotrexate oxidation in human, rat and mouse liver subcellular fractions

机译：常用有机溶剂对醛氧化酶介导的香兰素，酞嗪和甲氨蝶呤在人，大鼠和小鼠肝脏亚细胞级分中的氧化作用
- 作者：Behera Dayanidhi;Pattem Rambabu;Gudi Girish
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Aldehyde oxidase;
- cytochrome P450;
- IC50;
- LC/MS/MS;
- methotrexate;
- organic solvents;
- phthalazine;
- vanillin;
64.Pharmacokinetics of macrolactin A and 7-O-succinyl macrolactin A in mice

机译：大白蛋白A和7-O-琥珀酰大白蛋白A在小鼠中的药代动力学
- 作者：Jung Ji Won;Kim Ju Myung;Kwon Mi Hye;Kim Dong Hee;Kang Hee Eun
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- 7-O-succinyl macrolactin A;
- macrolactin A;
- mouse;
- pharmacokinetics;
- tissue distribution;
65.Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies

机译：具有人源化肝脏的嵌合啮齿动物：弥合ADME /毒性研究的临床前/临床试验差距
- 作者：Foster John R.;Lund Garry;Sapelnikova Svetlana;Tyrrell D. Lorne;Kneteman Norman M.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Animal to human extrapolation;
- cytochrome P450;
- DMPK;
- FRG mouse;
- hepatotoxicity;
- metabolism;
- TK-NOG mouse;
- uPA/SCID mouse;
66.In vitro metabolism of monensin A: microbial and human liver microsomes models

机译：莫能菌素A的体外代谢：微生物和人肝微粒体模型
- 作者：Rocha Bruno A.;Assis Marilda D.;Peti Ana P. F.;Moraes Luiz A. B.;Moreira Fernanda L.;Lopes Norberto P.;Pospisil Stanislav;Gates Paul J.;de Oliveira Anderson R. M.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Cytochrome P450;
- LC-ESI-MS/MS;
- mass spectrometry;
- microbial transformation;
- polyether ionophore;
67.Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies

机译：青蒿素抗疟药对重组色素和人肝微粒体体外细胞色素P450酶的影响：联合疗法的潜在影响
- 作者：Ericsson Therese;Sundell Jesper;Torkelsson Angelica;Hoffmann Kurt-Jurgen;Ashton Michael
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Artemether;
- artesunate;
- CYP enzymes;
- dihydroartemisinin;
- drug-drug interactions;
- inhibition;
68.Prediction of fraction metabolized via CYP3A in humans utilizing cryopreserved human hepatocytes from a set of 12 single donors

机译：利用来自一组12位单供体的冷冻保存的人肝细胞预测人体内经由CYP3A代谢的部分
- 作者：Desbans C.;Hilgendorf C.;Lutz M.;Bachellier P.;Zacharias T.;Weber J. C.;Dolgos H.;Richert L.;Ungell A. -L.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- CYP450 inhibition;
- DDI risk;
- hepatocytes suspension;
- ketoconazole;
- preclinical;
69.Species and sex-dependent toxicokinetics of 1-bromopropane: the role of hepatic cytochrome P450 oxidation and glutathione (GSH)

机译：1-溴丙烷的种类和性别依赖性毒代动力学：肝细胞色素P450氧化和谷胱甘肽（GSH）的作用
- 作者：Garner C. Edwin;Yu X.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- 1-Bromopropane;
- glutathione;
- P4502E1;
- toxicokinetics;
70.Pharmacokinetics and metabolite profiling of fimasartan, a novel antihypertensive agent, in rats

机译：新型抗高血压药氟马沙坦的药代动力学和代谢物谱
- 作者：Kim Tae Hwan;Shin Soyoung;Bashir Mohammad;Chi Yong Ha;Paik Soo Heui;Lee Joo Han;Choi Hyuk Joon;Choi Jin Ho;Yoo Sun Dong;Bulitta Juergen B.;Ma Eunsook;Joo Sang Hoon;Shin Beom Soo
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Angiotensin II receptor blocker;
- fimasartan;
- metabolite profiling;
- pharmacokinetics;
71.Characterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application of mdr1a knockout (-/-) rats into absorption study of multiple transporter substrate

机译：地高辛在大鼠中的胃肠道吸收特征，包括流入和流出转运蛋白：mdr1a基因敲除（-/-）大鼠在多种转运蛋白底物吸收研究中的应用
- 作者：Suzuki Motoya;Komura Hiroshi;Yoshikawa Tomonori;Enya Seiji;Nagao Akemi;Takubo Hiroaki;Kogayu Motohiro
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Absorption;
- digoxin;
- knockout rat;
- oatp;
- P-glycoprotein;
- quinidine;
72.The abundant dietary constituent ferulic acid forms a wide range of metabolites including a glutathione adduct when incubated with rat hepatocytes

机译：与大鼠肝细胞一起孵育时，丰富的膳食成分阿魏酸会形成多种代谢产物，包括谷胱甘肽加合物
- 作者：Omar Khaled;Grant M. Helen;Henderson Catherine;Watson David G.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Ferulic acid;
- FT-MS;
- GSH adduct;
- rat hepatocytes;
73.Modulatory effects of extracts of vinegar-baked Radix Bupleuri and saikosaponins on the activity of cytochrome P450 enzymes in vitro

机译：醋制柴胡和柴胡皂苷提取物对细胞色素P450酶活性的调节作用
- 作者：Yu Tongya;Chen Xianzhi;Wang Yinjie;Zhao Ruizhi;Mao Shirui
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Cytochrome P450 enzymes;
- modulate;
- saikosaponins;
- vinegar-baked Radix Bupleuri;
74.Role of hepatic blood flow and metabolism in the pharmacokinetics of ten drugs in lean, aged and obese rats

机译：肝血流量和代谢在瘦，老，肥胖大鼠中十种药物的药代动力学中的作用
- 作者：Subramanian Murali;Kurawattimath Vishwanath;Pocha Krishna;Freeden Chris;Rao Indranil;Mariappan T. Thanga;Marathe Punit H.;Vikramadithyan Reeba K.;Abraham Pamela;Kulkarni Chetan P.;Katnapally Prasanna;Nutakki Ravikumar;Paruchury Sundeep;Bhutani Priyadeep;Mandlekar Sandhya
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Altered clearance;
- CYP2E1;
- diet-induced obesity;
- efficacy models;
- hepatic blood flow;
- metabolism;
- pharmacokinetics;
- urinary clearance;
75.Effect of 36 CYP2C9 variants found in the Chinese population on losartan metabolism in vitro

机译：中国人群中36种CYP2C9变异体对氯沙坦体外代谢的影响
- 作者：Wang Yu-Han;Pan Pei-Pei;Dai Da-Peng;Wang Shuang-Hu;Geng Pei-Wu;Cai Jian-Ping;Hu Guo-Xin
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Allelic variant;
- catalytic activity;
- CYP2C9;
- losartan;
76.Metabolism-directed structure optimization of benzimidazole-based Francisella tularensis enoyl-reductase (FabI) inhibitors

机译：基于苯并咪唑的图拉弗朗西斯菌烯酰还原酶（FabI）抑制剂的代谢导向结构优化
- 作者：Zhang Yan-Yan;Liu Yong;Mehboob Shahila;Song Jin-Hua;Boci Teuta;Johnson Michael E.;Ghosh Arun K.;Jeong Hyunyoung
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Antibiotics;
- metabolism;
- microsome;
- optimization;
77.Pharmacokinetics of chlorogenic acid and corydaline in DA-9701, a new botanical gastroprokinetic agent, in rats

机译：绿原酸和Corydaline在新型植物胃肠动力药DA-9701中的药代动力学
- 作者：Jung Ji Won;Kim Ju Myung;Jeong Jin Seok;Son Miwon;Lee Hye Suk;Lee Myung Gull;Kang Hee Eun
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Chlorogenic acid;
- corydaline;
- DA-9701;
- pharmacokinetics;
- rats;
78.Impact of genetic deficiencies of P-glycoprotein and breast cancer resistance protein on pharmacokinetics of aripiprazole and dehydroaripiprazole

机译：P-糖蛋白和乳腺癌抗性蛋白遗传缺陷对阿立哌唑和脱氢阿立哌唑药代动力学的影响
- 作者：Nagasaka Yasuhisa;Sano Tomokazu;Oda Kazuo;Kawamura Akio;Usui Takashi
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Aripiprazole;
- brain penetration;
- breast cancer resistance protein;
- dehydroaripiprazole;
- knockout mouse;
- P-glycoprotein;
- mdr1a/1b;
- pharmacokinetics;
79.In vitro glucuronidation of Armillarisin A: UDP-glucuronosyltransferase 1A9 acts as a major contributor and significant species differences

机译：Armillarisin A的体外葡萄糖醛酸化作用：UDP-葡萄糖醛酸糖基转移酶1A9充当主要贡献者，并且物种之间存在显着差异
- 作者：Sun Dongxue;Zhu Liangliang;Xiao Ling;Xia Yangliu;Ge Guangbo;Cao Yunfeng;Wu Yan;Yin Jun;Yang Ling
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Armillarisin A;
- liver microsomal glucuronidation;
- species difference;
- UDP-glucuronosyltranferases;
80.The phoenix rises: a new science of in vivo drug metabolism PREFACE

机译：凤凰升起：体内药物代谢的新科学
- 作者：Samuelsson Kristin;Wilson Ian D.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
81.Absorption, metabolism and excretion of [C-14]gemigliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans

机译：新型二肽基肽酶4抑制剂[C-14] gemigliptin在人体内的吸收，代谢和排泄
- 作者：Kim Namtae;Patrick Lorna;Mair Stuart;Stevens Lloyd;Ford Gill;Birks Vicky;Lee Sung-Hack
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- DPP-4 inhibitor;
- human mass balance;
- pharmacokinetics;
82.Absorption, distribution, metabolism and excretion of gemigliptin, a novel dipeptidyl peptidase IV inhibitor, in rats

机译：新型二肽基肽酶IV抑制剂吉格列汀在大鼠中的吸收，分布，代谢和排泄
- 作者：Kim Yoon;Kim Unyong;Kim In Sook;Lee Sung-Hack;Lee Jaeick;Kim Dong-Hyun;Yoo Hye Hyun
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Absorption;
- distribution;
- excretion;
- gemigliptin;
- metabolism;
83.Metabolite elucidation of the Hsp90 inhibitor SNX-2112 using ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS)

机译：使用超高效液相色谱/四极杆飞行时间质谱（UPLC-QTOF / MS）鉴定Hsp90抑制剂SNX-2112的代谢物
- 作者：Liu Wei;Liu Hongming;Sun Hua;Dong Dong;Ma Zhiguo;Wang Yifei;Wu Baojian
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Anti-cancer drug;
- CYP metabolism;
- metabolynx;
- SNX-2112;
- UPLC-QTOF/MS;
84.Association analysis of three ABCB1 (MDR1) gene variants (C1236T, G2677A/T and C3435T) and their genotype/haplotype combinations with the familial Mediterranean fever

机译：三种ABCB1（MDR1）基因变异（C1236T，G2677A / T和C3435T）及其基因型/单倍型组合与家族性地中海热的关联分析
- 作者：Rustemoglu Aydin;Gumus-Akay Guvem;Karakus Nevin;Yigit Serbulent;Sahin Server;Tasliyurt Turker
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- ABCB1;
- FMF;
- haplotype;
- polymorphism;
- Turkey;
85.Metabolism of propyrisulfuron: C-14 excretion, C-14 concentration in plasma and tissues, and amount of metabolites in rats

机译：丙硫磺隆的代谢：大鼠体内的C-14排泄，血浆和组织中的C-14浓度以及大鼠体内的代谢物数量
- 作者：Takaku Tomoyuki;Mikata Kazuki;Nagahori Hirohisa;Sogame Yoshihisa
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Herbicide;
- metabolism;
- rat;
86.Bacterial beta-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics

机译：细菌β-葡萄糖醛酸苷酶抑制作用可保护小鼠免受吲哚美辛，酮洛芬或双氯芬酸诱导的肠病的影响：作用方式和药代动力学
- 作者：Saitta Kyle S.;Zhang Carmen;Lee Kang Kwang;Fujimoto Kazunori;Redinbo Matthew R.;Boelsterli Urs A.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Acyl glucuronide;
- gastrointestinal toxicity;
- glucuronide conjugate;
- Inhibitor-1;
- NSAIDs;
- phenol glucuronide;
- small intestinal ulcers;
87.The xenoestrogens ethinylestradiol and bisphenol A regulate BCRP at the blood-brain barrier of rats

机译：异雌激素乙炔雌二醇和双酚A调节大鼠血脑屏障中的BCRP
- 作者：Nickel Sabrina;Mahringer Anne
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- 17 alpha-Ethinylestradiol;
- bisphenol A;
- blood-brain barrier;
- breast cancer resistance protein;
- xenoestrogen;
88.Identification of UDP-glucuronosyltransferase isoforms responsible for leonurine glucuronidation in human liver and intestinal microsomes

机译：负责人肝脏和肠道微粒体中亮氨酸尿苷酸化的UDP-葡萄糖醛酸转移酶同工型的鉴定
- 作者：Tan Bo;Cai Weimin;Zhang Jinlian;Zhou Ning;Ma Guo;Yang Ping;Zhu Qing;Zhu Yizhun
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Intestine;
- leonurine;
- liver;
- metabolism;
- microsomes;
- UDP-glucuronosyltransferases;
89.Semi-physiological pharmacokinetic-pharmacodynamic modeling and simulation of 5-fluorouracil for the whole time course of alterations in leukocyte, neutrophil and lymphocyte counts in rats

机译：5-氟尿嘧啶在大鼠白细胞，中性粒细胞和淋巴细胞计数变化的全过程中的半生理药代动力学-药效学建模和模拟
- 作者：Kobuchi Shinji;Ito Yukako;Hayakawa Taro;Kuwano Shota;Baba Akiko;Shinohara Kota;Nishimura Asako;Shibata Nobuhito;Takada Kanji
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Cancer chemotherapy;
- PK-PD modeling;
- myelosuppression;
- simulations;
- toxicity;
90.In vitro cytotoxicity, pharmacokinetics and tissue distribution in rats of MXN-004, a novel conjugate of polyethylene glycol and SN38

机译：MXN-004（一种新型的聚乙二醇和SN38结合物）在大鼠中的体外细胞毒性，药代动力学和组织分布
- 作者：Zhou Sufeng;Li Ning;Wang Xin;Li Cuiyun;Tian Fengjie;Ren Shuangxia;Zhang Yuehua;He Yuanping;Qiu Zhixia;Zhao Di;Chen Xijing
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Cytotoxicity;
- PEGylation;
- pharmacokinetics;
- SN38;
- topoisomerase I inhibitors;
91.Comparative pharmacokinetic study of four major components after oral administration of pure compounds, herbs and Si-Ni-San to rats

机译：大鼠口服纯化合物，草药和Si-Ni-San后四种主要成分的比较药代动力学研究
- 作者：Wen Jing;Wang Yanjuan;Yang Lina;Zheng Weihua;Zhao Longshan;Li Famei
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Glycyrrhetinic acid;
- naringin;
- naringenin;
- paeoniflorin;
- pharmacokinetics;
- Si-Ni-San;
- UPLC-MS/MS;
92.In vitro and in vivo metabolism of a novel chymase inhibitor, SUN13834, and the predictability of human metabolism using mice with humanized liver

机译：新型食糜酶抑制剂SUN13834的体外和体内代谢以及使用人源化肝小鼠的人类代谢的可预测性
- 作者：Igawa Yoshiyuki;Fujitani Tomomichi;Shah Bharti;Oo Charles;Kanai Yasushi
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Chimeric mouse;
- chymase inhibitor;
- clinical study;
- cytochrome P450;
- SCID mouse;
- UDP-glucuronosyltransferase;
93.Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferases

机译：抑制尼罗替尼对人UDP-葡萄糖醛酸转移酶催化活性的选择性
- 作者：Ai Limei;Zhu Liangliang;Yang Lu;Ge Guangbo;Cao Yunfeng;Liu Yong;Fang Zhongze;Zhang Yanyan
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Niloinib;
- the selective inhibitor;
- UDP-glucuronosyltransferase 1A1;
94.Ethyl sulphate, a chemically reactive human metabolite of ethanol?

机译：硫酸乙酯，乙醇的一种化学反应性人类代谢产物？
- 作者：Mitchell Stephen C.;Waring Rosemary H.;Wilson Ian D.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Alkylation;
- ethanol;
- ethyl sulphate;
- ethylation;
95.Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism

机译：纤维肌痛的临床症状与儿茶酚-O-甲基转移酶（COMT）基因Val158Met多态性相关
- 作者：Inanir Ahmet;Karakus Nevin;Ates Omer;Sezer Saime;Bozkurt Nihan;Inanir Sema;Yigit Serbulent
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Catechol-O-methyltransferase;
- fibromyalgia;
- pain;
- Val158Met polymorphism;
96.Curiosities in drug metabolism

机译：药物代谢的好奇心
- 作者：Mitchell Stephen C.;Waring Rosemary H.;Smith Robert L.
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Aminopyrine;
- chlorphentermine;
- phenothiazine;
- pyramidone;
- rubazonic acid;
97.A new approach on methamphetamine-induced hepatotoxicity: involvement of mitochondrial dysfunction

机译：甲基苯丙胺诱导的肝毒性的新方法：线粒体功能障碍的参与
- 作者：Eskandari Mohammad Reza;Rahmati Mokhtar;Khajeamiri Ali Reza;Kobarfard Farzad;Noubarani Maryam;Heidari Himan
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Hepatotoxicity;
- liver injury;
- methamphetamine;
- mitochondrial dysfunction;
- oxidative stress;
98.Troglitazone metabolism and transporter effects in chimeric mice: a comparison between chimeric humanized and chimeric murinized FRG mice

机译：曲格列酮在嵌合小鼠中的代谢和转运蛋白作用：嵌合人源化和嵌合鼠源化FRG小鼠之间的比较
- 作者：Samuelsson Kristin;Pickup Kathryn;Sarda Sunil;Foster John R.;Randall Kevin;Abrahamsson Anna;Jacobsen Matt;Weidolf Lars;Wilson Ian
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- Chimeric mice;
- FRG mouse;
- human hepatocytes;
- PXB mouse;
- troglitazone;
99.Effect of saikosaponins and extracts of vinegar-baked Bupleuri Radix on the activity of beta-glucuronidase

机译：皂苷和醋制柴胡提取物对β-葡萄糖醛酸苷酶活性的影响
- 作者：Chen Xianzhi;Yu Tongya;Chen Zhenxing;Zhao Ruizhi;Mao Shirui
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- 4-Nitrophenyl-beta-D-glucuronide;
- beta-glucuronidase;
- saikosaponins;
- vinegar-baked Radix Bupleuri (VBRB);
100.Comparison of intestinal metabolism of CYP3A substrates between rats and humans: application of portal-systemic concentration difference method

机译：大鼠和人类之间CYP3A底物肠道代谢的比较：门脉系统浓度差异法的应用
- 作者：Kadono Keitaro;Koakutsu Akiko;Naritomi Yoichi;Terashita Shigeyuki;Tabata Kenji;Teramura Toshio
- 期刊名称：《Xenobiotica: the fate of foreign compounds in biological systems》 | 2014年第12期
- CYP3A;
- intestinal metabolism;
- species difference;

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有出版物经营许可证

客服微信
服务号