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首页> 外文会议>World biomaterials congress >Porcine anorganic bone mineral for guided bone regeneration in dental surgeries. Part Ⅱ: In vivo animal study and human case study
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Porcine anorganic bone mineral for guided bone regeneration in dental surgeries. Part Ⅱ: In vivo animal study and human case study

机译：猪无机骨矿物质，用于牙科手术中的引导性骨再生。第二部分：体内动物研究与人类案例研究

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Introduction: The development and in vitro characterization of the Porcine Anorganic Bone Mineral (PABM) were presented in part Ⅰ of this series. In part Ⅱ we summarize the results from a canine intrabony defect model to validate the characteristics of PABM as an effective bone conductive matrix in supporting bone growth and regeneration. The use of PABM for maxillary bone augmentation in sinus lifting and socket bone augmentation in humans is presented. Methods: In Vivo Intrabony Defect Study in Canines: Five beagle dogs had the third pre-molars (P3) extracted from the mandible. After 14 weeks post-extraction healing, each animal had a bilateral defect created, filled with PABM and covered with a marketed collagen membrane (MatrixDerm~®, Collagen Matrix, Inc.). At pre-determined time points (4, 8 and 12-weeks), explants were collected, fixed, and processed for histological analysis. Key parameters evaluated included cellular responses, bone healing activity and residual implant material. Human Case Studies: Case 1 was a maxillary sinus GBR procedure, using PABM and a collagen membrane (MatrixDerm~®, Collagen Matrix, Inc.), performed on a 50-year-old female patient (See Fig. 2 for details of the procedure). Case 2 was a bone augmentation in a socket extraction site on a 65-year-old male. The defect site was filled with PABM, covered with a collagen membrane (MatrixFlex~®, Collagen Matrix, Inc.) and sutured in place. Implant placement was performed 5 months post grafting and healing was uneventful. The tooth was fully restored (photos not shown). Results and Discussion: In Vivo Intrabony Defect Study in Canines: Histoligically, the total amount of bone and mature lamellar bone increased over time. Implantation of PABM supported bone regeneration (Fig. 1). The amount of implant material decreased slightly over the course of the study. PABM was nonirritant at all time intervals. Human Case Study: Figure 2 showed an example of use of PABM and collagen membrane to augment maxillary bone defect. The quality and maturity of bone formation at 6 months were adequate for implant placement and final restoration. The clinical cases presented here demonstrate that the combination of PABM and collagen membrane can work in various dental implant surgeries requiring GBR procedures. Conclusion: The use of a bone conductive matrix in conjunction with a membrane for GBR procedure has become a prerequisite step in the overall success of dental implantology. Our overall goal is to develop an ideal bone conductive matrix that will be accessible to clinicians. The in vitro characterization, animal study and human case studies presented here have demonstrated that PABM can fulfill the requirements for GBR applications.
机译：简介：本系列的第一部分介绍了猪无机骨矿物质（PABM）的开发和体外特性。在第二部分中，我们总结了犬骨内缺损模型的结果，以验证PABM作为支持骨生长和再生的有效骨传​​导基质的特征。提出了PABM在人类窦内提升和上颌骨增强中上颌骨增强的用途。方法：犬的体内骨内缺陷研究：五只比格犬从下颌骨中提取出第三颗前磨牙（P3）。拔牙后愈合14周后，每只动物均产生双侧缺陷，充满PABM并覆盖有市售的胶原蛋白膜（MatrixDerm®，Collagen Matrix，Inc.）。在预定的时间点（4、8和12周），收集外植体，固定并处理以进行组织学分析。评估的关键参数包括细胞反应，骨愈合活性和残余植入物材料。人类案例研究：案例1是上颌窦GBR手术，使用PABM和胶原膜（MatrixDerm®，Collagen Matrix，Inc.）对50岁的女性患者进行了手术（有关细节，请参见图2）。程序）。案例2是一名65岁男性在拔牙窝处的骨增加。缺损部位充满PABM，覆盖胶原膜（MatrixFlex®，Collagen Matrix，Inc.），并缝合在适当位置。移植后5个月进行植入物植入，愈合良好。牙齿已完全恢复（照片未显示）。结果与讨论：犬的体内骨内缺损研究：从历史上看，骨骼和成熟层状骨骼的总量随时间增加。 PABM植入支持骨再生（图1）。在研究过程中，植入材料的数量略有减少。 PABM在所有时间间隔均无刺激性。人体案例研究：图2显示了使用PABM和胶原膜增强上颌骨缺损的示例。 6个月时骨形成的质量和成熟度足以用于植入物植入和最终修复。此处介绍的临床病例证明，PABM和胶原膜的结合可以在需要GBR程序的各种牙科植入手术中发挥作用。结论：在GBR手术中使用骨传导基质和膜结合已成为牙科种植学全面成功的先决条件。我们的总体目标是开发一种理想的骨传导基质，让临床医生可以使用。这里介绍的体外表征，动物研究和人类案例研究表明，PABM可以满足GBR应用的要求。

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