• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Periodontology >Bone regeneration of localized chronic alveolar defects utilizing cell binding peptide associated with anorganic bovine-derived bone mineral: a clinical and histological study.
【24h】

Bone regeneration of localized chronic alveolar defects utilizing cell binding peptide associated with anorganic bovine-derived bone mineral: a clinical and histological study.

机译：利用与无机牛源性骨矿物质相关的细胞结合肽对局部慢性肺泡缺损进行骨再生：一项临床和组织学研究。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Osteoinduction to treat osseous defects has been attempted by several means. Some clinical studies have demonstrated that a synthetic cell binding peptide (P-15) with anorganic bovine derived bone matrix (ABM) has the ability to enhance bone regeneration. These studies suggest that more histological data are necessary to better understand this process. We have developed a Class III chronic alveolar defect animal model to investigate space-maintaining regenerative materials. The objective of this study was to clinically and histologically evaluate the use of P-15/ABM with or without a bioabsorbable membrane (M) to regenerate localized chronic alveolar ridge defects in dogs. METHODS: Six adult, male mongrel dogs were used in this study. Bilateral, Class III, alveolar defects were surgically produced following extraction of the mandibular second premolar teeth and local reduction of the alveolar ridge. After an 8-week healing interval, mucoperiosteal flaps were elevated. P-15/ABM with or without bioabsorbable membranes were implanted into contralateral defects in 10 sites. Two sites received no biomaterial (controls). Mucoperiosteal flaps were advanced over the P-15/ABM or P-15/ABM/M constructs and sutured. Pre- and postaugmentation clinical evaluation was done utilizing periodontal probes and calipers. The animals were sacrificed 12 weeks postaugmentation and block specimens processed for histologic evaluation. RESULTS: Clinical results showed no significant statistical augmentation on the control group (0.0 +/- 0.6 mm). In all experimental sites utilizing P-15/ABM or P-15/ABM/M, relevant ridge augmentation was observed (3.6 +/- 2.0 mm and 2.9 +/- 1.9 mm, respectively). Histologically, all experimental sites showed active bone formation with plump osteoblast and osteoid matrix deposition in the treated area. Bone ingrowth filled the area of the defects treated with P-15/ABM/M. Few P-15/ABM particles were seen in the cellular fibrous tissue surrounding the new formed bone trabeculae. CONCLUSIONS: P-15/ABM with or without membranes can produce a significant clinical ridge augmentation. Bone formation was histologically observed in all test areas. The association of a membrane with P-15/ABM seemed to enhance the process of bone formation.
机译：背景：通过多种方法尝试了骨诱导治疗骨缺损。一些临床研究表明，具有无机牛衍生骨基质（ABM）的合成细胞结合肽（P-15）具有增强骨再生的能力。这些研究表明，更多的组织学数据对于更好地理解这一过程是必要的。我们已经开发了III类慢性牙槽缺损动物模型，以研究维持空间的再生材料。这项研究的目的是在临床和组织学上评估在有或没有生物可吸收膜（M）的情况下P-15 / ABM在犬中再生局部慢性牙槽chronic缺损的用途。方法：本研究使用六只成年雄性杂种狗。下颌第二颗前磨牙拔除并局部减少牙槽following后，通过手术产生了双侧，III类肺泡缺损。在8周的愈合间隔后，粘膜骨膜瓣被抬高。将具有或不具有生物可吸收膜的P-15 / ABM植入10个部位的对侧缺陷中。两个地点没有收到生物材料（对照）。粘膜骨膜瓣在P-15 / ABM或P-15 / ABM / M构建体上前进并缝合。使用牙周探针和卡尺进行强化前和强化后的临床评估。扩增后12周处死动物，并处理块状样本以进行组织学评估。结果：临床结果显示，对照组（0.0 +/- 0.6毫米）没有统计学上的显着增加。在所有使用P-15 / ABM或P-15 / ABM / M的实验点中，均观察到了相关的隆起（分别为3.6 +/- 2.0 mm和2.9 +/- 1.9 mm）。从组织学上讲，所有实验部位均在受治疗区域显示出活跃的骨形成，丰满的成骨细胞和类骨质基质沉积。骨长入充满了用P-15 / ABM / M处理的缺损区域。在新形成的骨小梁周围的细胞纤维组织中几乎看不到P-15 / ABM颗粒。结论：具有或不具有膜的P-15 / ABM均可产生明显的临床牙增大。从组织学上观察所有测试区域的骨形成。膜与P-15 / ABM的结合似乎增强了骨形成的过程。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号