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首页> 外文会议>World biomaterials congress >Silver particle integrated covering self-expandable metal stent reduces biofilm formation and stent-induced inflammation
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Silver particle integrated covering self-expandable metal stent reduces biofilm formation and stent-induced inflammation

机译：集成了银颗粒的覆盖物，可覆盖自膨胀金属支架，可减少生物膜形成和支架诱发的炎症

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One of main issues in clinical use of covered self-expandable biliary metal stent is a biofilm formation on the surface of polymeric covered membranes which lead to cholangitis and stent obstruction.Anti-biofilm formation is needed to prolong stent patency and reduce adverse events. This experimental study aimed to estimate the efficacy of anti-biofilm covered self-expandable metal stent in porcine model.Following deployment of test and control stent during 8 weeks in biliary dilatation model, the extents of biofilm formation and histopathological difference were estimated. In our in vivo study, silver particle integrated covering self-expandable metal stent reduced biofilm formation and stent-related pathological tissue changes compared with conventional covering self-expandable metal stent.
机译：覆膜自膨胀胆管金属支架临床使用的主要问题之一是在聚合物覆膜表面形成生物膜，导致胆管炎和支架阻塞。需要形成抗生物膜以延长支架通畅并减少不良事件。本实验旨在评估抗生物膜覆盖的自膨胀金属支架在猪模型中的疗效。在胆道扩张模型中放置8周的测试和对照支架后，评估生物膜形成的程度和组织病理学差异。在我们的体内研究中，与传统的覆盖物自膨胀金属支架相比，集成有银颗粒的覆盖物覆盖了自膨胀金属支架，减少了生物膜的形成，减少了与支架相关的病理组织的变化。

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