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首页> 外文会议>Annual conference of the International Society of Exposure Science >Can worker dermal exposure predictions be improved based on current data sets?
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Can worker dermal exposure predictions be improved based on current data sets?

机译：可以根据当前数据集改善工人的皮肤接触预测吗？

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Aims and background Occupational exposure models have been developed to estimate dermal exposure concentrations (or ranges) to hazardous chemicals. In spite of the acceptance of these tools, however, these models have not been comprehensively validated. In this part of the symposium the validation of the dermal of ECETOC TRA will be presented, as an example of the possibilities to improve dermal models based on currently available data. Methods In a project sponsored by CEFIC-LRI, the dermal model of ECETOC TRA is validated using published dermal exposure measurement. TRA exposure estimates are compared with exposure levels presented in public available literature, creating an overview of available exposure measurement data. When improvements of more resolution in dermal exposure models is needed, insight in dermal exposure determinants and dermal exposure processes is needed. Availability of information on these elements is investigated in two recent initiatives to improve dermal exposure assessment, namely the BROWSE project (www. browseproject.eu) and during the development of a dermal module of the Advanced REACH Tool (dART). Results and conclusions Although we know quite a lot about dermal exposure process, good quality information on exposure to underpin our exposure models is scares and fragmented. An uniform format to collect and store exposure data is missing. Furthermore, agreement on standard measuring methods is lacking. In addition, the dermal exposure process is rather complex, with various processes like dermal loading, dermal transfer, resuspension and cleaning are important. The effect of different determinants on these processes has not been systematically investigated yet. If we want to improve the current assessment methods for dermal exposure in the workplace, a clear and coordinated research program is needed.
机译：目的和背景已经开发了职业接触模型来估计有害化学物质的皮肤接触浓度（或范围）。尽管接受了这些工具，但是这些模型尚未得到全面验证。在研讨会的这一部分中，将介绍ECETOC TRA真皮的验证，作为基于当前可用数据改进真皮模型的可能性的示例。方法在由CEFIC-LRI赞助的项目中，使用公开的皮肤暴露测量结果验证了ECETOC TRA的皮肤模型。将TRA暴露估算值与公开文献中提供的暴露水平进行比较，以概述可用暴露测量数据。当需要改善皮肤暴露模型的分辨率时，需要深入了解皮肤暴露决定因素和皮肤暴露过程。在最近两项旨在改善皮肤暴露评估的计划中，即BROWSE项目（www。Browseproject.eu）和高级REACH工具（dART）的皮肤模块开发过程中，对这些元素的信息可用性进行了研究。结果与结论尽管我们对皮肤接触过程了解很多，但关于风险的高质量信息却令人恐惧且支离破碎。缺少用于收集和存储曝光数据的统一格式。此外，在标准测量方法上缺乏共识。此外，皮肤暴露过程相当复杂，重要的是各种过程，例如皮肤加载，皮肤转移，再悬浮和清洁。尚未系统研究不同决定因素对这些过程的影响。如果我们想改善当前工作场所中皮肤暴露的评估方法，则需要一个清晰而协调的研究计划。

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