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首页> 外文会议>Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Comparing glucose and insulin data from the two-hour oral glucose tolerance test in metabolic syndrome subjects and marathon runners
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Comparing glucose and insulin data from the two-hour oral glucose tolerance test in metabolic syndrome subjects and marathon runners

机译：比较代谢综合征受试者和马拉松运动员两小时口服葡萄糖耐量试验的葡萄糖和胰岛素数据

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Glucose is the main energy source of the body's cells and is essential for normal metabolism. Two pancreatic hormones, insulin and glucagon, are involved in glucose home-ostasis. Alteration in the plasma glucose and insulin concentrations could lead to distinct symptoms and diseases, ranging from mental function impairment to coma and even death. Type 2 diabetes, insulin resistance and metabolic syndrome are typical examples of abnormal glucose metabolism that increase the risk for cardiovascular disease and mortality. The oral glucose tolerance test (OGTT) is a medical test used to screen for prediabetes, type 2 diabetes and insulin resistance. In the 5-sample 2-hour OGTT, plasma glucose and insulin concentrations are measured after a fast and then after oral intake of glucose, at intervals of 30 minutes. In this work, a statistical analysis is carried out to find significant differences between the five stages of the OGTT for plasma glucose and insulin data. In addition, the behavior of the glucose and insulin data is compared between subjects with the metabolic syndrome and marathon runners. Results show that marathon runners have plasma glucose and insulin levels significantly lower (p <; 0.05) than people with the metabolic syndrome in all the stages of the OGTT. Insulin secretion decreases in marathon runners due to a significant reduction in plasma glucose concentration, but insulin secretion does not decrease in metabolic syndrome subjects due to insulin resistance, consequently plasma glucose concentration does not achieve normal levels.
机译：葡萄糖是人体细胞的主要能量来源，对于正常的新陈代谢至关重要。葡萄糖稳态中涉及两种胰激素，胰岛素和胰高血糖素。血浆葡萄糖和胰岛素浓度的改变可能导致不同的症状和疾病，从精神功能障碍到昏迷甚至死亡。 2型糖尿病，胰岛素抵抗和代谢综合征是异常葡萄糖代谢的典型例子，这些异常葡萄糖代谢会增加心血管疾病和死亡的风险。口服葡萄糖耐量测试（OGTT）是一种医学测试，用于筛查糖尿病前期，2型糖尿病和胰岛素抵抗。在5个样本的2小时OGTT中，在禁食后，口服葡萄糖摄入后（间隔30分钟）测量血浆葡萄糖和胰岛素浓度。在这项工作中，进行了统计分析，以发现OGTT的五个阶段之间血浆葡萄糖和胰岛素数据之间的显着差异。另外，在患有代谢综合症的受试者和马拉松运动员之间比较了葡萄糖和胰岛素数据的行为。结果显示，在OGTT的所有阶段中，马拉松运动员的血浆葡萄糖和胰岛素水平均显着低于代谢综合征患者（p <; 0.05）。由于血浆葡萄糖浓度的显着降低，马拉松运动员的胰岛素分泌减少，但是由于胰岛素抵抗，在代谢综合症受试者中胰岛素分泌并未减少，因此血浆葡萄糖浓度未达到正常水平。

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