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Characterisation of microstructural changes during the hydration of pharmaceutical tablets using terahertz pulsed imaging

机译:使用太赫兹脉冲成像表征药物片剂水化过程中的微观结构变化

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Terahertz pulsed imaging (TPI) is used to characterise microstructural changes during the hydration of pharmaceutical tablets. In particular, terahertz reflection measurements provide quantitative information about the liquid penetration, swelling and the formation of cracks. X-ray computed microtomography (XμCT) is employed to characterise the microstructure of the dry powder compact in terms of porosity, equivalent volume diameter and length of the pores. Both XμCT and TPI can provide valuable information about the impact of the microstructure on the performance of drugs.
机译:太赫兹脉冲成像(TPI)用于表征药物片剂水化过程中的微结构变化。特别是,太赫兹反射测量可提供有关液体渗透,溶胀和裂纹形成的定量信息。 X射线计算机断层扫描(XμCT)用于根据孔隙率,当量体积直径和孔的长度来表征干粉压块的微观结构。 XμCT和TPI均可提供有关微观结构对药物性能影响的有价值的信息。

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