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首页> 外文会议>International ISA biomedical sciences instrumentation symposium;International Society of Automation;Annual Rocky Mountain bioengineering symposium >THE ANTINOCICEPTIVE EFFICACY OF CHRONIC FLUOXETINE TREATMENT
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THE ANTINOCICEPTIVE EFFICACY OF CHRONIC FLUOXETINE TREATMENT

机译：慢性氟西汀治疗的止痛效果

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Fluoxetine, a selective serotonin reuptake inhibitor, is one of the oldest second-generation antidepressants on the market. Recentstudies have shown that fluoxetine has antinociceptive effects, but the results were based on acute doses of the drug. Theobjective of our study was to compare the antinociceptive efficacy of two fluoxetine doses delivered acutely and chronicallyto a naïve control using adult male Sprague-Dawley rats and a model of acute thermal pain involving a hot plate analgesiometer(Omnitech Electronics, Inc.; Columbus, OH) set at 52.5°C. The treatment groups received 10 mg/kg or 20mg/kg of fluoxetinethat was delivered daily for two weeks or four months via Pillsbury sugar cookie dough. The naïve control group receivednothing. Each animal was habituated to the hot plate enclosure for one minute on the day prior to testing. For the study, eachrat was placed on the hot plate apparatus, and a built-in timer was started as soon as all four of the animal’s paws touched thesurface. The timer was stopped as soon as the animal displayed one of the following responses: paw lift, paw lick, or jump.Our results show that both chronic fluoxetine treatment groups had significantly longer latencies compared to the naïve controlgroup, and that the latencies between the two doses were not significantly different. Overall, our results indicate that long-termadministration of fluoxetine via cookie dough is capable of reducing the response to thermal stimuli.
机译：氟西汀是一种选择性的5-羟色胺再摄取抑制剂，是市场上最古老的第二代抗抑郁药之一。最近的 研究表明，氟西汀具有镇痛作用，但结果基于该药物的急性剂量。这 我们研究的目的是比较两种氟西汀的急性和慢性镇痛效果 使用成年雄性Sprague-Dawley大鼠和包含热板镇痛仪的急性热痛模型对幼稚的对照进行评估 （Omnitech Electronics，Inc .;俄亥俄州哥伦布）设定在52.5°C。治疗组接受10 mg / kg或20mg / kg的氟西汀 每天通过Pillsbury糖饼干面团送达两周或四个月。幼稚对照组 没有。在测试前一天，将每只动物习惯于在加热板上封闭一分钟。对于研究，每个 将老鼠放到热板设备上，一旦这四个动物的爪子都碰触到它，就会启动一个内置计时器。 表面。一旦动物表现出以下反应之一，计时器便停止：爪子抬起，舔舔或跳动。 我们的结果表明，与单纯对照组相比，两个长期氟西汀治疗组的潜伏期都明显更长 组，并且两次剂量之间的潜伏期没有显着差异。总体而言，我们的结果表明，长期 通过曲奇面团施用氟西汀可以减少对热刺激的反应。

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