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The effect of hypothermic machine perfusion and cold storage for kidney preservation

机译：低温机器灌注和冷藏对肾脏保存的影响

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Currently, two principles of the kidney preservation (hypothermic machine perfusion; HMP and cold storage; CS) are generally used in kidney transplantation. Both HMP and CS are developed base on the suitable conditions that can maintain the kidney function. In this study, the vascular impedance of kidney was investigated. This experiment aims to comparison the impedance between HMP and CS methods by using a kidney of pig from slaughterhouse. The protocol of impedance estimation, after the kidney was remove from pig (mixed breed pigs), it was gravity flushing to wash blood out. After that, each kidneys were measured impedance before the preservation method. For HMP method, other 3 kidneys were preserved with continuous flow of Euro's Collins preservation solution that maintain pressure around 40 ± 5 mmHg at temperature 4-6 °C for 24 hours. For CS method, 3 kidneys were kept in chamber that filled with Euro's Collins preservation solution at temperature 4-6 °C for 24 hours. After 24 hours, impedance estimation was performed. Results: from the first impedance estimation, both HMP and CS impedances were 0.957±0.95 and 1.024±0.05 mmHg min/ml, respectively. After 24 hours, the impedance of HMP method were higher than CS method (1.059±0.09 and 1.028±0.009 respectively). Conclusion, the kidney preservation using HMP show higher impedance than CS method because the autoregulation in the kidney vascular system that effect to the metabolite phenomenon. Therefore, the HMP preservation can preserving kidneys better than CS preservation.
机译：当前，肾脏移植中通常使用两种保存肾脏的原则（低温机灌注; HMP和冷藏; CS）。 HMP和CS都是在可以维持肾脏功能的适当条件下开发的。在这项研究中，研究了肾脏的血管阻抗。本实验旨在通过使用屠宰场的猪肾脏来比较HMP和CS方法之间的阻抗。阻抗估算的规程是，从猪（混种猪）中取出肾脏后，进行重力冲洗以洗出血液。之后，在保存方法之前，测量每个肾脏的阻抗。对于HMP方法，使用Euro's Collins防腐液连续流动保存其他3个肾脏，该溶液在4-6°C的温度下保持约40±5 mmHg的压力达24小时。对于CS方法，将3个肾脏置于充满Euro Collins保存溶液的小室中，温度为4-6°C，持续24小时。 24小时后，进行阻抗估计。结果：从第一次阻抗估计中，HMP和CS阻抗分别为0.957±0.95和1.024±0.05 mmHg min / ml。 24小时后，HMP法的阻抗高于CS法（分别为1.059±0.09和1.028±0.009）。结论，使用HMP进行肾脏保存比CS方法具有更高的阻抗，因为肾脏血管系统中的自动调节会影响代谢物现象。因此，HMP的保存比CS的保存能更好地保存肾脏。

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