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Continuous cardiac perfusion preservation with PEG-HB for improved hypothermic storage
Continuous cardiac perfusion preservation with PEG-HB for improved hypothermic storage
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机译：PEG-HB连续心脏灌注保存可改善低温保存
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摘要
Efforts to extend myocardial preservation for transplantation by perfusion with prior crystalloid based solutions have been limited by edema and compromised function. Hypothermic perfusion preservation with a polyethylene glycol (PEG) conjugated hemoglobin solution extends preservation times. The polyethylene glycol (PEG) conjugated hemoglobin solution comprises PEG-Hb, and at least one of the constituents selected from the group of human albumin, dextrose, heparin sodium, lidocaine HCl, MgSO4, KCl, CaCl2, Tromethamine (THAM) solution, NaCl, NaHCO3, and Na2HPO4/NaH2PO4. Comparison of cardiac function after continuous perfusion using a hypocalcemic normokalemic crystalloid perfusate is made with and without the addition of PEG-Hemoglobin (Hb).
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机译：水肿和功能受损限制了通过灌注现有的基于晶体的溶液来延长心肌保存以进行移植的努力。用聚乙二醇（PEG）共轭血红蛋白溶液进行低温灌注保存可以延长保存时间。聚乙二醇（PEG）共轭血红蛋白溶液包含PEG-Hb，以及选自人白蛋白，右旋糖，肝素钠，利多卡因HCl，MgSO 4 ，KCl，CaCl中的至少一种成分 2 ，三甲胺（THAM）溶液，NaCl，NaHCO 3 和Na 2 HPO 4 / NaH 2 PO 4 。在添加和不添加PEG-血红蛋白（Hb）的情况下，使用低血钙正常血型晶体灌注液对连续灌注后的心功能进行比较。
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