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首页> 外文会议>IEEE International Conference on Bioinformatics and Bioengineering >The Relevance of Upstream and Downstream Regions of mRNA in the Prediction of Translation Initiation Site of the Protein
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The Relevance of Upstream and Downstream Regions of mRNA in the Prediction of Translation Initiation Site of the Protein

机译：mRNA的上游和下游区域在蛋白质翻译起始位点的预测中的相关性

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The correct prediction of Protein Translation Initiation Site is a problem of considerable interest in the molecular biology. In the literature, some papers investigate conservative positions of the mRNA that favor an ideal context for begin of translation, as it is the case of the work of Kozak. The Kozak Consensus is known to reveal some important mRNA upstream region positions to recognize an early translation. This work investigated the real contribution of these conservative positions, besides analyzing sequences in the downstream region to be considered the non-initiators of translation. In this paper, we use the Support Vector Machine classifier and three different scenarios. The results indicate that the proposed methodology was efficient, guaranteeing a gain in the performance of the larger organisms. For the smaller organisms, the three scenarios investigated maintain the same behavior. However, due to the lack of consideration of the upstream region of the mRNA, the proposed methodology allows evaluating organisms not considered in other works, as is the case of the Caenorhabditis elegans organism.
机译：蛋白质翻译起始位点的正确预测是分子生物学中相当感兴趣的问题。在文献中，一些文献研究了mRNA的保守位置，这些位置有利于理想的翻译起点，例如Kozak的作品。众所周知，《 Kozak共识》揭示了一些重要的mRNA上游区域位置，以识别早期翻译。这项工作除了分析了下游区域被认为是翻译非启动子的序列之外，还研究了这些保守位置的真正贡献。在本文中，我们使用支持向量机分类器和三种不同的方案。结果表明，所提出的方法是有效的，从而保证了较大生物体性能的提高。对于较小的生物，所研究的三种情况保持相同的行为。但是，由于不考虑mRNA的上游区域，因此所提出的方法可以评估其他工作中未考虑的生物，如秀丽隐杆线虫的情况。

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