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首页> 外文会议>Annual conference of the International Society of Exposure Science >A Suspect Screening Method for Characterizing Multiple Chemical Exposures among a Demographically Diverse Population of Pregnant Women in San Francisco, CA
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A Suspect Screening Method for Characterizing Multiple Chemical Exposures among a Demographically Diverse Population of Pregnant Women in San Francisco, CA

机译：一种可疑筛查方法，用于表征加利福尼亚州旧金山市人口不同的孕妇群体中的多种化学暴露

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In utero exposure to multiple environmental chemicals can adversely impact pregnancy outcomes and increase risks of disease throughout the lifespan. To better understand human exposure to potentially hundreds of environmental chemicals, we perform a suspect screen for the presence of 725 Environmental Organic Acids (EOAs) in maternal serum, to characterize the exposure profile of EOAs, and to identify novel chemicals, using liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF/MS). We analyzed serum samples collected at delivery from 83 pregnant women receiving care at San Francisco General Hospital and UCSF Mission Bay Medical Center, using Agilent LC 1260-QTOF/MS 6550. We examined demographic differences in detection frequency (DF) and peak areas of candidate compounds using a Fisher's exact test, analysis of variance, or Kruskal-Wallis Rank Sum test. We confirmed prioritized suspect compounds by running their reference standards. We detected, on average, 60 (SD: 8) suspect EOAs in each sample (range: 34-87), the majority of which were matched to phenols and phenolic pesticide metabolites. There were 15 suspect EOAs with high DF (>80%) in our sample population, over half of which were potential novel chemicals that have not been previously biomonitored. We found differences by race/ethnicity, household income, and education in DF for several suspect EOAs as well as in relative concentration (measured by peak areas) for some highly detected suspect EOAs. We confirmed the presence of 6 novel compounds maternal serum: 2,4-Di-tert-butylphenol, 2,4-Dinitrophenol, Pyrocatechol, 3,5-Di-tert-butylsalicylic acid, 4-Hydroxycoumarin, and 3'-Hydroxyacetophenone. Suspect screening approaches to biomonitoring for environmental chemicals provides a viable method to more holistically characterize a broad spectrum of environmental chemicals and to identify novel, ubiquitously present compounds and thus prioritize chemicals for targeted method development.
机译：在UTERO暴露于多种环境化学物质中可能对妊娠结果产生不利影响，并增加整个寿命的疾病风险。为了更好地了解人体暴露于潜在数百种环境化学品，我们在母体血清中表现出725个环保有机酸（EOAs）的可疑筛网，以表征EOAs的曝光谱，并使用液相色谱法鉴定新化学品。四极杆飞行时间质谱（LC-QTOF / MS）。我们分析了在旧金山综合医院和UCSF Mission Bay Medical Center的83名孕妇收集的血清样本，使用Agilent LC 1260-QTOF / MS 6550。我们检查了检测频率（DF）和候选峰面积的人口差异使用Fisher精确测试的化合物，方差分析或Kruskal-Wallis等级测试。我们通过运行其参考标准确认优先嫌疑组化合物。我们平均检测到60（SD：8）在每个样品中可疑EOAs（范围：34-87），其中大多数与酚类和酚类农药代谢物相匹配。在我们的样本人口中有15名可疑的EOAS，其中一半以上，其中一半是潜在的新化学品，尚未以前的生物制作。我们发现了几个嫌疑人EOAS中的种族/种族，家庭收入和教育的差异，以及一些高度检测到的嫌疑人EOAs的相对集中（峰值区域）。我们确认存在6个新型化合物母体血清：2,4-二叔丁基苯酚，2,4-二硝基苯酚，PercocateChol，3,5-二叔丁基磺酰酸，4-羟基苏格林和3'-羟基乙酮。怀疑环境化学品的生物监测方法的筛选方法提供了一种可行的方法，以更全面地表征广谱的环境化学品，并鉴定新颖的，普遍存在的化合物，从而优先考虑靶向方法的化学品。

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