• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Annual conference of the International Society of Exposure Science >Variability of bisphenol-A concentrations in first morning, bedtime, and 24-hour urine samples in 50 North Carolina adults over a six-week period
【24h】

Variability of bisphenol-A concentrations in first morning, bedtime, and 24-hour urine samples in 50 North Carolina adults over a six-week period

机译：在六周的时间内，北卡罗莱纳州的50名成年人中，第一早，就寝时间和24小时尿液样本中双酚A浓度的变化

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Bisphenol-A (BPA) is a high-production volume chemical that is used to make a number of consumer products and packaged goods. Many cross-sectional studies have frequently reported detecting BPA in urine. However, limited data exist on the temporal variability of urinary BPA concentrations. The major objectives of this study were to: 1) quantify the levels of BPA in first-morning void (FMV), bedtime, and 24-hour samples as concentration, specific gravity (SG) corrected, creatinine (CR) corrected, and excretion rate values for 50 adults over a six-week monitoring period; and 2) determine if these correction approaches decreased the variability in urinary BPA levels. In 2009-2011, a convenience sample of 50 adults (19-50 years old) was recruited from residential settings in North Carolina. Participants collected urine samples (FMV, bedtime, and 24-hour) during weeks 1, 2, and 6 of the six-week monitoring period. Urine samples (n=2335) were analyzed for total BPA concentrations by high-performance liquid chromatography/tandem mass spectrometry. The preliminary data show that BPA was frequently detected (98%) in all of the urine samples. Median levels of BPA were consistently the highest in 24-hour samples (2.08 ng/mL, 2.36 ng/mL-SG, 2.53 ng/mg-CR, and 2.64 ng/min) and the lowest in FMV samples (1.73 ng/mL, 1.61 ng/mL-SG, 1.64 ng/mg-CR, and 1.38 ng/min) across all four methods. Intraclass correlation coefficient (ICC) estimates for BPA showed poor reproducibility (≤ 0.40) for all urine sample types and methods over a day, week, and six weeks. The highest ICC value of 0.40 occurred for CR-corrected bedtime voids collected over a week. To obtain a reliable average biomarker estimate (ICC=0.80) for BPA, these results indicate that at least six bedtime urine measurements would be needed per adult over a week. In conclusion, these results suggest that bedtime voids may be the preferred sample type to collect in future studies to adequately assess BPA exposures in adults.
机译：双酚A（BPA）是一种高产量的化学品，用于制造许多消费品和包装商品。许多横断面研究经常报告检测到尿液中的BPA。但是，关于尿液BPA浓度随时间变化的数据有限。这项研究的主要目的是：1）根据浓度，校正的比重（SG），校正的肌酐（CR）和排泄物，对初次排尿（FMV），就寝时间和24小时样品中的BPA含量进行定量在六个星期的监测期内为50名成年人提供的费率值;和2）确定这些校正方法是否降低了尿液BPA水平的变异性。在2009-2011年，从北卡罗来纳州的居民区招募了50名成年人（19-50岁）的便利样本。参与者在为期六周的监测期的第1、2和6周收集了尿液样本（FMV，就寝时间和24小时）。通过高效液相色谱/串联质谱分析尿液样本（n = 2335）中的总BPA浓度。初步数据表明，在所有尿液样本中都经常检测到BPA（98％）。 BPA中位数在24小时样本中始终最高（2.08 ng / mL，2.36 ng / mL-SG，2.53 ng / mg-CR和2.64 ng / min），而在FMV样本中最低（1.73 ng / mL ，四种方式的1.61 ng / mL-SG，1.64 ng / mg-CR和1.38 ng / min）。 BPA的类内相关系数（ICC）估计显示，在一天，一周和六周内，所有尿液类型和方法的重现性均很差（≤0.40）。一周内收集到的经CR校正的就寝空隙的最高ICC值为0.40。为了获得双酚A的可靠平均生物标志物估计值（ICC = 0.80），这些结果表明，每个成年人在一周内至少需要进行六次就寝时间尿液测量。总之，这些结果表明，就寝时间可能是在未来的研究中收集的首选样本类型，以充分评估成年人的BPA暴露量。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号