Conclusions: This study concludes that the nanobubbles fabricated through the nanoprecipitation method are smaller in size. Furthermore, ACN has a significant effect on the size of the nanobubbles. The drug loading capacity of the PLGA nanobubbles fabricated through this method is high enough which supports drug delivery. Future studies will include surface functionalization of PLGA nanobubbles with targeting ligands. Perfluorocarbons can enhance the ultrasound image while the nanobubbles are attached to the blood vessels around the tumor. When the imaging is completed, for the diagnostic purpose, the frequency of the applied ultrasound can be adjusted in a way that the nanobubbles disintegrate and release the therapeutic agent locally.
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