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首页> 外文会议>International conference on design theory and methodology;ASME international design engineering technical conferences and computers and information in engineering conference >INTEGRATIVE DESIGN, BUILD, TEST APPROACH FOR BIOMEDICAL DEVICES WITH LATTICE STRUCTURES
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INTEGRATIVE DESIGN, BUILD, TEST APPROACH FOR BIOMEDICAL DEVICES WITH LATTICE STRUCTURES

机译：具有格子结构的生物医学设备的集成设计，构建，测试方法

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Advances in 3D printing are enabling new rapid prototyping strategies for complex structures, such as mechanically efficient tissue scaffolds. Here, we have developed an integrated methodology with Design, Build, and Test phases to characterize beam-based lattices for bone tissue engineering. Lattices were designed with 50% and 70% porosity with beam diameters of 0.4mm to 1.0mm fabricated with polyjet printing. Build accuracy was validated with microscopy that demonstrated overall lattice dimensions were at most 0.2mm different from design and beam diameters were at most 0.15mm different. Quasi-static compression testing showed lattice elastic moduli ranged from 28MPa to 180MPa and decreased with higher lattice porosity but increased with larger beam diameter sizes. Scaffold cages for vertebral bone fusion were prototyped using 50% and 70% porous lattices with 0.8mm diameter beams with added central voids for improved nutrient transport, reinforced shells for increased mechanics, or both. Cage stiffnesses ranged from 1.7kN/mm to 7.2kN/mm and suggests the strongest cage prototypes are suitable for carrying typical spinal loads of up to 1.65kN. The study demonstrates the value in using integrated rapid prototyping approaches for characterizing complex structures and designing novel biomedical devices.
机译：3D打印技术的进步为复杂结构（例如机械效率高的组织支架）提供了新的快速原型开发策略。在这里，我们开发了一种具有设计，构建和测试阶段的集成方法，以表征用于骨组织工程的基于梁的晶格。格设计成具有50％和70％的孔隙度，并采用多喷印刷法制造束直径为0.4mm至1.0mm的束。通过显微镜验证了构建精度，该显微镜显示出整个晶格尺寸与设计最多相差0.2mm，光束直径最多相差0.15mm。准静态压缩试验表明，晶格弹性模量在28MPa至180MPa之间，并随着较高的晶格孔隙率而降低，但随较大的束径尺寸而增加。用于椎骨融合的支架笼的原型是使用直径为0.8mm的50％和70％的多孔网格，带有增加的中央空隙以改善营养传输，增强的外壳以提高机械强度，或两者兼而有之。保持架的刚度范围为1.7kN / mm至7.2kN / mm，这表明最坚固的保持架原型适用于承受高达1.65kN的典型脊柱负荷。这项研究证明了使用集成的快速原型设计方法表征复杂结构和设计新型生物医学设备的价值。

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