Immobilization of BMP-2 within a Poly(Ethylene Glycol) Hydrogel to Induce Osteogenesis in Serum-Free Conditions

机译：在无血清条件下将BMP-2固定在聚（乙二醇）水凝胶中以诱导成骨作用

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BMP-2 was necessary to induce osteogenesis of MSCs in the photoclick hydrogels in defined medium. A simple bioconjugation strategy to thiolate BMP-2 maintains biological activity and can be tethered into the PEG network. Current work is investigating the effects of tethered BMP-2 on osteogenesis of encapsulated MSCs through biochemical assays, immuno-histochemical staining, and gene expression.

机译：BMP-2是诱导在限定培养基中的光点击水凝胶中MSC的成骨作用所必需的。一种简单的生物共轭策略可以使BMP-2硫醇化，从而保持了生物活性，可以被束缚到PEG网络中。当前的工作是通过生物化学分析，免疫组织化学染色和基因表达研究拴系BMP-2对封装的MSCs成骨的影响。

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《Society for Biomaterials annual meeting and exposition》|2018年|73-73|共1页
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Michael L. Trombold; Stephanie J. Bryant;
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2. A comparison of human mesenchymal stem cell osteogenesis in poly(ethylene glycol) hydrogels as a function of MMP-sensitive crosslinker and crosslink density in chemically defined medium [J] . Aziz Aaron H., Bryant Stephanie J. Biotechnology and Bioengineering . 2019,第6期

机译：聚（乙二醇）水凝胶中人间充质干细胞骨质发生的比较作为化学定义培养基中的MMP敏感交联剂和交联密度的函数
3. Supramolecular hydrogels induced rapidly by inclusion complexation of Poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) block copolymers with alpha-cyclodextrin in aqueous solutions [J] . Zhao SP, Zhang LM, Ma D The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical . 2006,第25期

机译：聚（ε-己内酯）-聚（乙二醇）-聚（ε-己内酯）嵌段共聚物与α-环糊精在水溶液中的包合络合作用迅速诱导了超分子水凝胶
4. Immobilization of BMP-2 within a Poly(Ethylene Glycol) Hydrogel to Induce Osteogenesis in Serum-Free Conditions [C] . Michael L. Trombold, Stephanie J. Bryant Society for Biomaterials annual meeting and exposition . 2018

机译：在聚（乙二醇）水凝胶中的BMP-2固定化，以诱导无血清条件下的骨性发生
5. Mechanical conditioning of photopolymerized chondrocyte-laden poly(ethylene glycol) hydrogels for cartilage tissue engineering. [D] . Nicodemus, Garret Devon. 2009

机译：软骨组织工程用光聚合载有软骨细胞的聚乙二醇水凝胶的机械调理。
6. Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels [O] . Jennifer E. Saik, Daniel J. Gould, Emily M. Watkins, -1

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7. A comparison of human mesenchymal stem cell osteogenesis in poly(ethylene glycol) hydrogels as a function of MMP‐sensitive crosslinker and crosslink density in chemically defined medium [O] . Aaron H. Aziz, Stephanie J. Bryant 2019

机译：聚（乙二醇）水凝胶中人间充质干细胞骨质发生的比较作为化学定义培养基中的MMP敏感交联剂和交联密度的函数

Immobilization of BMP-2 within a Poly(Ethylene Glycol) Hydrogel to Induce Osteogenesis in Serum-Free Conditions

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