Our results indicate that microvesicles released from highly aggressive breast carcinoma cells phenotypically alter epithelial and stromal cells. We additionally show that microvesicles release from invasive and noninvasive subpopulations of these heterogeneous cancer cells have different protein compositions. The phenotypic changes caused by cancer cell-derived microvesicles and the difference in protein content from subpopulation-derived microvesicles may play a role in the development of the pre metastatic niche. Future work will further address differences between subpopulation-derived microvesicles and their contributions towards the tumor stroma and development of a pre metastatic niche.
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