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首页> 外文会议>Society for Biomaterials annual meeting and exposition >A mechanistic study of anti-HIV activity and cancer registry match investigation in laboratory drug 2- Indolinones show record linkage among them many interesting leads evaluation
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A mechanistic study of anti-HIV activity and cancer registry match investigation in laboratory drug 2- Indolinones show record linkage among them many interesting leads evaluation

机译：实验室药物2-吲哚啉酮的抗HIV活性机理和癌症登记匹配研究的机理研究表明，它们之间的记录联系很多有趣的线索评估

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Statement of Purpose: It is well documented that HIV infection dramatically increases the risk for various cancers. However the risks for cancers overall and specifically by different types among HIV-positive individuals in India are largely unknown and it is generally felt that these risks are lower than that reported in other populations. The little that is known about the association of HIV and malignancies in India stems from case reports and hospital based studies. There have been very few cases reported of Kaposi's sarcoma and hospital based prevalence studies of HIV in cancers have found rates ranging from 1 to 4%. One hospital based study which analysed data on testing of cancer patients (Cancer Causes and Control 2008; 19; 147-153) has provided some preliminary estimates in the form of Proportional Incidence Ratios (PIRs) which confirmed the preliminary impression that Kaposi's sarcoma is rarely observed in HIV infected individuals in India. The study found increased PIRs for non-Hodgkin's lymphoma (NHL) and anal cancer in males and females, increased PIR for cervical and vaginal cancer in females and Hodgkin's disease, testicular cancer, colon cancer, and several head and neck cancer sites in men. However there have been no populations based studies to assess the risk of different cancers in HIV. It is well accepted that such studies which minimise selection, response and referral biases would be able to provide better estimates of cancer risk for different anatomical sites among HIV infected persons in a region. Systematic monitoring of cancer burden is therefore important both from a public health and from a clinical management perspective to maximize the benefits of a resource intensive intervention. Record linkage is a well-recognized tool to study the morbidity and mortality patterns in a population in general or in a particular area. Matching of HIV and Cancer registry's has been found to be a useful tool for understanding HIV and Cancer epidemiology in many developed countries of the world (USA, UK, Australia, Italy) and also in Uganda. It was felt however that this kind of a linkage study would not be possible in India due to lack of unique identification number for matching and databases (especially small molecule drug discovery part). The approach can be used in bioinformatics practices, to take this study further, a laboratory work focused on interesting finding novel lead molecule of 2- Indolinones showed such record-linkage in multiple anti cancerous and HIV-1 activity.
机译：目的陈述：有据可查的是，艾滋病毒感染会大大增加罹患各种癌症的风险。但是，在印度，总体上，尤其是在艾滋病毒呈阳性的人群中，癌症的风险尤其是不同类型癌症的风险尚不明确，人们普遍认为这些风险低于其他人群中报告的风险。在印度，关于艾滋病毒和恶性肿瘤相关性的鲜为人知的原因是病例报告和医院研究。很少有关于卡波济肉瘤的报道，基于医院的艾滋病毒在癌症中的患病率研究发现，这一比例为1-4％。一项基于医院的研究对癌症患者的测试数据进行了分析（Cancer Causes and Control 2008; 19; 147-153）以比例发生率（PIRs）的形式提供了一些初步估计，证实了初步的印象，即卡波西氏肉瘤很少在印度的HIV感染者中观察到。该研究发现，男性和女性非霍奇金淋巴瘤（NHL）和肛门癌的PIR增加，女性宫颈和阴道癌的PIR增加，男性霍奇金病，睾丸癌，结肠癌以及男性的一些头颈癌部位增加。但是，还没有基于人群的研究来评估艾滋病毒中不同癌症的风险。公认的是，将选择，反应和转诊偏倚减至最少的此类研究将能够更好地估计该地区HIV感染者不同解剖部位的癌症风险。因此，从公共卫生和临床管理的角度出发，系统地监测癌症负担对于使资源密集型干预措施的收益最大化是非常重要的。记录链接是一种公认​​的工具，可以用来研究总体或特定地区人群的发病率和死亡率。在世界上许多发达国家（美国，英国，澳大利亚，意大利）以及乌干达，发现艾滋病毒和癌症登记册的匹配是了解艾滋病毒和癌症流行病学的有用工具。但是，由于缺乏用于匹配和数据库的唯一识别号（尤其是小分子药物发现部分），因此在印度不可能进行这种关联研究。该方法可用于生物信息学实践中，以使这项研究更进一步，实验室工作侧重于有趣地发现2-吲哚满酮的新型先导分子，显示出在多种抗癌和HIV-1活性中的这种记录联系。

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