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首页> 外文会议>IEEE International Conference on Big Data Computing Service and Applications >The Tumor Infiltrating Leukocyte Cell Composition Are Significant Markers for Prognostics of Radiotherapy of Rectal Cancer as Revealed by Cell Type Deconvolution
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The Tumor Infiltrating Leukocyte Cell Composition Are Significant Markers for Prognostics of Radiotherapy of Rectal Cancer as Revealed by Cell Type Deconvolution

机译：肿瘤浸润白细胞的细胞组成是直肠癌放疗预后的重要标志，如细胞类型反卷积所揭示

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Tumor tissues consist of various types of cells including cancer stem cells, base cells, tumor infiltrated immune cells, and even new types of cancer associated cells. The tumor infiltrating cells play important roles in cancer progression and prognosis. Using present web servers and standalone tools of cell type deconvolution, including Timer, CIBERSORT, xCell, we deconvoluted the immune cell composition of microarray gene expression profiles of rectal cancer tissues collected from the rectal cancer patients before radiotherapy operation. By comparing the cell type composition obtained by timer of the rectal tissues from the radiotherapy responsive patients with those of non-responsive patients, we found that the content of CD4+ cells has average content of 0.1378 versus 0.1071 with p=0.0215; the ratio of CD4+/CD8+ is averaged 0.7869 versus 0.5564 with p=0.0210; and T cells CD4 memory resting and Eosinophils are both significantly higher with p-value of 0.033 and 0.0206, respectively, in radiotherapy responsive rectal cancer patient than in non-responsive cancer patients. The content of CD8+ cells are lower in the responsive than in non-responsive patients, which is averaged 0.1798 versus 0.2104 with p=0.0239. Other significant different cell types include macrophages M1 and M2, adipocytes, plasma cells and preadipocytes. Patients can be classified into responsive and non-responsive by machine learning method based on the tumor infiltrating immune cell composition with accuracy of 65%. It will be investigated that if the results can be applied to our newly collected data of other type of cancers including lung and nasopharyngeal carcinoma cancers in the future.
机译：肿瘤组织由各种类型的细胞组成，包括癌症干细胞，基础细胞，肿瘤浸润的免疫细胞，甚至是新型的癌症相关细胞。肿瘤浸润细胞在癌症进展和预后中起重要作用。使用当前的网络服务器和细胞类型反卷积的独立工具，包括Timer，CIBERSORT，xCell，我们对放射治疗操作前从直肠癌患者收集的直肠癌组织的微阵列基因表达谱的免疫细胞组成进行反卷积。通过比较按计时器从放射治疗反应性患者和无反应性患者的直肠组织中获得的细胞类型组成，我们发现CD4 +细胞的平均含量为0.1378，而平均含量为0.1071，p = 0.0215; CD4 + / CD8 +的比率平均为0.7869，而平均值为0.5564，p = 0.0210;放射治疗反应性直肠癌患者的T细胞CD4和T细胞CD4记忆静止和嗜酸性粒细胞的P值分别显着高于0.033和0.0206，而非反应性癌症患者的P-值分别为0.033和0.0206。有反应的患者中CD8 +细胞的含量低于无反应的患者，平均为0.1798比0.2104，p = 0.0239。其他重要的不同细胞类型包括巨噬细胞M1和M2，脂肪细胞，浆细胞和前脂肪细胞。根据肿瘤浸润的免疫细胞组成，通过机器学习方法可以将患者分为反应性和非反应性，准确度为65％。我们将调查是否可以将结果应用到我们最近收集的其他类型癌症（包括肺癌和鼻咽癌）的数据中。

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