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首页> 外文会议>IEEE Portuguese Meeting in Bioengineering >Assessing the molecular fingerprint of T lymphocyte activation
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Assessing the molecular fingerprint of T lymphocyte activation

机译：评估T淋巴细胞活化的分子指纹

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Methods to evaluate Lymphocyte T function, are very important in clinical context, namely in patients with primary and secondary immunodeficiencies, bone marrow or hematopoietic stem cell transplantation, organ transplant and immunosuppressive therapy. However, the conventional monitoring techniques are based on laborious, expensive methods. In the present work, it was evaluated the potential of an infrared spectroscopy based-method, in the assessment of lymphocyte T function after mitogen activation. It was possible to discriminate, either by principal component analysis either by hierarchical cluster analysis of second derivative spectra of lymphocytes T, between resting T cells and activated T cells. The infrared spectroscopy-based method presents therefore a high potential for a new diagnostic tool of the T cell alloreactivity.
机译：评估淋巴细胞T功能的方法在临床上非常重要，即在患有原发性和继发性免疫缺陷，骨髓或造血干细胞移植，器官移植和免疫抑制疗法的患者中。但是，常规的监视技术是基于费力的，昂贵的方法。在目前的工作中，评估了有丝分裂原活化后淋巴细胞T功能评估中基于红外光谱法的潜力。有可能通过主成分分析或通过对淋巴细胞T的二阶导数光谱进行分级聚类分析来区分静息T细胞和活化T细胞之间的关系。因此，基于红外光谱的方法为T细胞同种异体反应的新诊断工具提供了很高的潜力。

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