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CULTURE MEDIUM COMPOSITION FOR CULTURING OF ANTI-CANCER ACTIVATED LYMPHOCYTES DERIVED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS AND METHOD FOR CULTURING ANTI-CANCER ACTIVATED LYMPHOCYTES USING SAME
CULTURE MEDIUM COMPOSITION FOR CULTURING OF ANTI-CANCER ACTIVATED LYMPHOCYTES DERIVED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS AND METHOD FOR CULTURING ANTI-CANCER ACTIVATED LYMPHOCYTES USING SAME
The present invention relates to a culture medium composition for culturing anti-cancer activated lymphocytes derived from peripheral blood mononuclear cells and a method for culturing anti-cancer activated lymphocytes using same. More specifically, when the composition contains normal hexane fraction of Melia azedarach L., interleukin-2 (IL-2), anti-CD3 monoclonal antibody, and anti-CD16 monoclonal antibody, the effects of promoted differentiation and of mass proliferation of NK cells, NKT cells, and T cells (corresponding to anti-cancer activated lymphocytes) from peripheral blood mononuclear cells were confirmed. Accordingly, the present invention relates to a culture composition based on normal hexane fraction of Melia azedarach L. and a method for culturing peripheral blood mononuclear cells using same. Also, the anti-cancer activated lymphocytes derived from peripheral blood mononuclear cells cultured by the method according to the present invention can be used as a pharmaceutical composition which is highly effective for cancer treatment. Furthermore, the culture medium composition of the present invention may itself be used as an anti-cancer treatment, and when a chemical anticancer drug is administered in combination in a clinical use, the dosage of an existing anti-cancer drug can be lowered, thereby relieving side effects and greatly enhancing anticancer activity.
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