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首页> 外文会议>International IEEE/EMBS Conference on Neural Engineering >Kilohertz Frequency Stimulation of Renal Nerves for Modulating Blood Glucose Concentration in Diabetic Rats
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Kilohertz Frequency Stimulation of Renal Nerves for Modulating Blood Glucose Concentration in Diabetic Rats

机译：肾神经的千赫兹频率刺激以调节糖尿病大鼠的血糖浓度

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In recent years, the role of the kidney in glucose homeostasis has gained global interest. The kidneys are innervated by renal nerves, and renal denervation studies to control hypertension have shown improved glucose regulation. We hypothesized that kilohertz frequency stimulation, which can block propagation of action potentials, applied to renal nerves would reduce blood glucose concentration levels by increasing urinary glucose excretion. We performed experiments on 8 anesthetized, streptozotocin-induced diabetic rats. The renal nerves were encircled by a cuff electrode. Blood glucose concentrations were obtained from tail blood samples. Urine glucose concentrations were obtained from bilateral cannulation of the ureters. Electrical stimulation (50 kHz, 15 V) was applied for 60 minutes. The average blood glucose concentration rate was lower during stimulation (-0.78 ± 1.20 mg/dL/min), compared to before stimulation (+1.14 ± 1.83 mg/dL/min; p <; 0.05) and after stimulation (+0.63 ± 1.32 mg/dL/min). The average area under the curve for urine glucose concentration was higher during stimulation (7687.4 ± 4006.1 mg/dL) compared to before (6466.9 ± 2772.8 mg/dL) and after stimulation (5277.2 ± 3381.5 mg/dL). Overall, our results show that kilohertz frequency stimulation of renal nerves is a possible approach for the modulation of blood glucose concentration and may introduce an alternative treatment modality for glycemic control in patients with diabetes.
机译：近年来，肾脏在葡萄糖稳态中的作用已引起全球关注。肾脏被肾神经支配，控制神经变性的肾脏神经支配研究显示改善了葡萄糖的调节。我们假设施加到肾神经的千赫兹频率刺激（可以阻止动作电位的传播）会通过增加尿中葡萄糖的排泄来降低血糖浓度水平。我们对8只麻醉的链脲佐菌素诱导的糖尿病大鼠进行了实验。袖带电极环绕着肾神经。从尾巴血液样品中获得血糖浓度。从输尿管的双侧插管获得尿液中的葡萄糖浓度。施加电刺激（50 kHz，15 V）60分钟。与刺激前（+1.14±1.83 mg / dL / min; p <; 0.05）和刺激后（+0.63±1.32）相比，刺激期间（-0.78±1.20 mg / dL / min）的平均血糖浓度较低。毫克/分升/分钟）。刺激期间尿液葡萄糖浓度曲线下的平均面积（7687.4±4006.1 mg / dL）高于刺激之前和之前（6466.9±2772.8 mg / dL）和刺激后（5277.2±3381.5 mg / dL）。总体而言，我们的结果表明，以千赫兹频率刺激肾神经是调节血糖浓度的一种可能方法，并且可能为糖尿病患者的血糖控制引入替代治疗方式。

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