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首页> 外文会议>Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Mathematical Modeling of Neurostimulation for Post-traumatic Stress Disorder: A Migration Towards Multiscale Modeling to Assess Neural Response to Transcranial Direct Current Stimulation Treatments
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Mathematical Modeling of Neurostimulation for Post-traumatic Stress Disorder: A Migration Towards Multiscale Modeling to Assess Neural Response to Transcranial Direct Current Stimulation Treatments

机译：用于创伤后应激障碍的神经刺激的数学模型：向多尺度模型迁移以评估对经颅直流电刺激治疗的神经反应

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摘要

Post-traumatic stress disorder (PTSD) is a neurological condition which results from a traumatic experience caused by physiological shock or physical harm. Clinical results show success in combating the symptoms of PTSD with a neurostimulation treatment called transcranial Direct Current Stimulation (tDCS). Though effective, the underlying mechanisms of the treatment and its success are not fully comprehended. In order to elucidate reasons for its efficacy, a mathematical model of tDCS has been implemented to quantify the electrical energy delivered by this treatment. Computational simulation results of various PTSD-focused electrode montages on a three-dimensional, MRI-derived cranial cavity with biologically-based tissue conductivities parallel results from published literature and clinical experiments. Specifically, regions of the brain thought to be targeted by tDCS treatments are confirmed with in silico experiments. Finally, an extension of this model to a unique multiscale mathematical model of tDCS is presented, which adds the ability to quantify neural tissue response via tDCS-induced transmembrane voltage polarization, the first of its kind for tDCS simulations for PTSD.
机译：创伤后应激障碍（PTSD）是一种神经系统疾病，由生理性休克或身体伤害引起的创伤经历引起。临床结果表明，采用经颅直流电刺激（tDCS）的神经刺激疗法可以成功地克服PTSD的症状。尽管有效，但尚不能完全理解治疗的潜在机制及其成功。为了阐明其功效的原因，已经实施了tDCS的数学模型来量化该处理所传递的电能。在以生物学为基础的组织电导率为生物学基础的三维三维颅腔上，以PTSD为中心的各种电极蒙太奇的计算仿真结果均与已发表的文献和临床实验结果相平行。具体而言，通过计算机实验证实了被tDCS治疗靶向的大脑区域。最后，提出了将该模型扩展到tDCS的独特多尺度数学模型的方法，该模型增加了通过tDCS诱导的跨膜电压极化来量化神经组织反应的能力，这是PTSD的tDCS模拟的第一个此类方法。

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