Conclusions: We have identified notable trends in HSC phenotypic and functional responses quantified by Lox expression, cell proliferation and cell contractility experiments. These studies highlight key microenvironmental regulators of HSC phenotype and function, which can provide a foundation for the development of novel drugs to reverse NASH-associated fibrosis. Further, such high-throughput studies can also help us develop disease models of NASH associated fibrosis to study the exact mechanism of the progression of disease in humans. Ongoing efforts are focused on examining the underlying mechanisms behind HSC responsiveness to microenvironmental changes.
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