pH-sensitive Liposomes as Drug Carriers for the Treatment of Brain Infection Diseases

机译：pH敏感脂质体作为治疗脑感染疾病的药物载体

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All results obtained for TAT-functionalized liposomes, including their low MIC with respect to the use of free antibiotic plus their remarkable high percentage of cell viability with astrocytes and endothelial cells, provides evidence that this liposomal system can be a safe, alternative means for treating bacterial meningitis. The next steps in this research will look at more BBB studies, and the study of the effect of the liposome treatment on the genetic properties of the bacterial cell membrane, to better understand their cell uptake mechanism. This work was supported by funds from Northeastern University.

机译：TAT功能化脂质体的所有结果，包括使用游离抗生素的最低MIC，以及与星形胶质细胞和内皮细胞的显着高细胞活力百分比，均证明该脂质体系统可以作为一种安全的替代治疗方法细菌性脑膜炎。这项研究的下一步将着眼于更多的BBB研究，以及脂质体处理对细菌细胞膜遗传特性的影响的研究，以更好地了解其细胞摄取机制。这项工作得到了东北大学的资助。

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《Society for Biomaterials annual meeting and exposition》|2019年|524-524|共1页
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Caterina Bartomeu Garcia; Di Shi; Thomas J. Webster;
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1. Liposomes as carriers of enzymes or drugs: a new approach to the treatment of storage diseases [J] . B E Ryman, G Gregoriadis The biochemical journal . 1971,第5期

机译：脂质体作为酶或药物的载体：治疗储存疾病的新方法
2. Polydopamine-coated liposomes as pH-sensitive anticancer drug carriers [J] . Zong Wei, Hu Ying, Su Yingchun, Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres . 2016,第1a8期

机译：聚多巴胺涂层脂质体作为pH敏感的抗癌药物载体
3. Novel pH-sensitive drug carriers of carboxymethyl-hexanoyl chitosan (Chitosonic (R) Acid) modified liposomes [J] . Hardiansyah Andri, Huang Li-Ying, Yang Ming-Chien, RSC Advances . 2015,第30期

机译：羧甲基己酸壳聚糖（Chitosonic（R）酸）修饰脂质体的新型pH敏感药物载体
4. pH-sensitive Liposomes as Drug Carriers for the Treatment of Brain Infection Diseases [C] . Caterina Bartomeu Garcia, Di Shi, Thomas J. Webster Society for Biomaterials annual meeting and exposition . 2019

机译：pH敏感的脂质体作为药物载体用于治疗脑感染疾病
5. Hybrid Thermosensitive Liposome -- Nanoparticle Drug Carrier with Triggered Release. [D] . Forbes, Natalie A. 2014

机译：混合热敏脂质体-触发释放的纳米药物载体。
6. Smart Drug Carriers: PEGylated TATp-Modified pH-Sensitive Liposomes [O] . AMIT A. KALE, VLADIMIR P. TORCHILIN -1

机译：智能药物载体：PEG化TATp修饰的pH敏感脂质体
7. Liposomes as carriers of enzymes or drugs: a new approach to the treatment of storage diseases. [O] . Gregoriadis, G, Ryman, B E 1971

机译：脂质体作为酶或药物的载体：治疗储存疾病的新方法。
8. Guidelines for the Prevention and Treatment of Opportunistic Infections Among HIV-Exposed and HIV-Infected Children: Recommendations from CDC, the National Institutes of Health, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the American Academy of Pediatrics. Morbidity and Mortality Weekly Report, Vol. 58, August 26, 2009. Early Release [R] . 2009

机译：艾滋病暴露和艾滋病毒感染儿童机会性感染的预防和治疗指南：疾病预防控制中心，美国国立卫生研究院，美国传染病学会艾滋病医学协会，儿科传染病学会和美国的建议儿科学院。发病率和死亡率周报，Vol。 58，2009年8月26日。早期发布

pH-sensitive Liposomes as Drug Carriers for the Treatment of Brain Infection Diseases

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