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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Polydopamine-coated liposomes as pH-sensitive anticancer drug carriers
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Polydopamine-coated liposomes as pH-sensitive anticancer drug carriers

机译：聚多巴胺涂层脂质体作为pH敏感的抗癌药物载体

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摘要

Stimuli-responsive drug carriers are considered to play important roles in chemotherapy. We fabricated pH-sensitive polydopamine-protected liposomes (liposome@PDA) drug delivery systems, which were characterised with microscope, scanning electron microscope (SEM), UV-vis spectrometer and Fourier transform infrared (FTIR) technieques. The typical chemotherapeutic agent, 5-fluorouracil (5-FU), was loaded into liposome@PDA capsules. The maximum release percentages of 5-FU are 3.2%, 29.5%, 52.7%, 76.7% in the solution with pH 7.42, 6.87, 4.11 and 3.16, respectively. The in vitro cell cytotoxity experiments were carried out using 5-FU-loaded capsules at pH 6.87 solution, which simulate the true pH around cancerous cells. At 1.5M concentration, the free 5-FU, 5-FU-loaded liposome capsules and 5-FU-loaded capsules showed the cell viability of 50.56%, 22.66% and 21.63%, respectively. It confirms that drug-loaded capsules performed better than free drug. The results demonstrate the great potential of liposome@PDA capsules as carriers in biomedical applications.
机译：刺激反应性药物载体被认为在化学疗法中起重要作用。我们制造了对pH敏感的聚多巴胺保护的脂质体（liposome @ PDA）药物递送系统，通过显微镜，扫描电子显微镜（SEM），紫外可见光谱仪和傅里叶变换红外（FTIR）技术对其进行了表征。将典型的化学治疗药物5-氟尿嘧啶（5-FU）装入脂质体PDA胶囊中。在pH 7.42、6.87、4.11和3.16的溶液中，5-FU的最大释放百分比分别为3.2％，29.5％，52.7％，76.7％。体外细胞毒性实验是使用装有5-FU的胶囊在pH 6.87溶液中进行的，该胶囊模拟癌细胞周围的真实pH。在1.5M浓度下，游离的5-FU，5-FU脂质体胶囊和5-FU胶囊分别显示出50.56％，22.66％和21.63％的细胞活力。它证实了载药胶囊的性能优于游离药物。结果证明脂质体@PDA胶囊在生物医学应用中作为载体的巨大潜力。

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