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首页> 外文会议>International Workshop on Breast Imaging >Diagnostic performance of integrated digital breast tomosynthesis (DBT) and molecular breast tomosynthesis (MBT) among women scheduled for breast biopsy
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Diagnostic performance of integrated digital breast tomosynthesis (DBT) and molecular breast tomosynthesis (MBT) among women scheduled for breast biopsy

机译：计划进行乳房活检的女性中，数字化乳房断层合成（DBT）和分子乳房断层合成（MBT）的诊断性能

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The value of adding ~(99m)Tc- sestamibi MBT to the current clinical standard of DBT plus 2D digital mammography (MM) was assessed. Images were acquired using a dual modality tomosynthesis (DMT) scanner designed to obtain superimposable DBT and MBT images. Seventy-five subjects with 83 biopsied lesions were scanned prior to biopsy. A blinded MQSA-certified breast radiologist with limited nuclear medicine (NM) experience viewed the images in the following sequence: 1) DBT alone, 2) add MM, and 3) add MBT (equivalent to DMT+MM). MM images were from each subject's most recent clinical mammographic exam. At each stage, all findings were scored using a 5-point suspicion scale ranging from l=definitely benign, to 5=definitely malignant. Independently, a blinded, experienced NM radiologist scored all MBT scans without access to the DBT or MM images, using the same suspicion scale. The NM results were provided to the breast radiologist reader following their 3-stage evaluation, and a fourth suspicion score was recorded for all findings. Using location-confirmed biopsy results as ground truth, ROC curves and the areas under the curves, A_z were generated for each of the four stages, and for MBT alone. Compared to DBT+MM, the changes in A_z for MBT alone, DBT, and DMT+MM were +21.4% (p<0.02), -22.1% (p<0.01), +25.2% (p<0.002), respectively. Addition of the NM report to DMT+MM had no measurable effect on ROC shape or A_z value. These results suggest that hybrid tomosynthesis can potentially improve DBT diagnostic performance; that breast radiologists with limited nuclear medicine experience might nevertheless effectively utilize MBT information; and that stand-alone MBT could be a valuable complementary tomographic modality.
机译：评估在DBT加上2D乳腺X线摄影术（MM）的当前临床标准中添加〜（99m）Ts-sestamibi MBT的价值。使用双模态断层合成（DMT）扫描仪获取图像，该扫描仪旨在获得可叠加的DBT和MBT图像。在进行活检之前，对75名有83个活检病变的受试者进行了扫描。一位具有有限核医学（NM）经验的盲人MQSA认证乳腺放射科医生按以下顺序查看图像：1）仅DBT，2）添加MM和3）添加MBT（相当于DMT + MM）。 MM图像来自每个受试者最近的临床乳房X线检查。在每个阶段，均使用5分怀疑量表对所有发现进行评分，该量表的范围从l =良性到5 =恶性。独立地，一位盲人，经验丰富的NM放射科医生使用相同的可疑等级对所有MBT扫描进行评分，而无法访问DBT或MM图像。在进行3阶段评估后，将NM结果提供给乳腺放射线医学阅读器，并记录所有发现的第四个可疑分数。使用位置确认的活检结果作为地面真相，ROC曲线和曲线下的面积，针对四个阶段的每个阶段以及仅针对MBT生成A_z。与DBT + MM相比，仅MBT，DBT和DMT + MM的A_z变化分别为+ 21.4％（p <0.02），-22.1％（p <0.01），+ 25.2％（p <0.002）。将NM报告添加到DMT + MM对ROC形状或A_z值没有可测量的影响。这些结果表明，混合断层合成可以潜在地改善DBT的诊断性能。然而，核医学经验有限的乳腺放射科医生仍可能有效地利用MBT信息;而独立的MBT可能是X线断层扫描的一种有价值的补充。

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