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Disruption of structural brain networks in Primary Open Angle Glaucoma

机译：原发性开角型青光眼的结构性脑网络的破坏。

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Primary open angle glaucoma (POAG) is one of the most common causes of permanent blindness in the world. Recent studies have originated the hypothesis that POAG could be considered as a central nervous system pathology which results in secondary visual involvement. The aim of this study is to assess possible structural whole brain connectivity alterations in POAG by combining multi-shell diffusion weighted imaging, multi-shell multi-tissue probabilistic tractography, graph theoretical measures and a newly designed disruption index, which evaluates the global reorganization of brain networks in group-wise comparisons. We found global differences in structural connectivity between Glaucoma patients and controls, as well as in local graph theoretical measures. These changes extended well beyond the primary visual pathway. Furthermore, group-wise and subject-wise disruption indices were found to be statistically different between glaucoma patients and controls, with a positive slope. Overall, our results support the hypothesis of a whole-brain structural reorganization in glaucoma which is specific to structural connectivity, possibly placing this disease within the recently defined groups of brain disconnection syndrome.
机译：原发性开角型青光眼（POAG）是世界上造成永久性失明的最常见原因之一。最近的研究提出了这样的假设，即POAG可以被认为是导致继发视力受累的中枢神经系统病理。这项研究的目的是通过结合多壳弥散加权成像，多壳多组织概率束摄影术，图形理论方法和新设计的破坏指数来评估POAG中可能的结构性全脑连通性改变，该评估旨在评估POAG的全球重组。分组比较中的大脑网络。我们发现青光眼患者与对照之间在结构连接性方面存在全局差异，以及在局部图论中存在理论差异。这些变化远远超出了主要的视觉途径。此外，青光眼患者和对照组之间的群体和受试者的破坏指数在统计学上是不同的，具有正斜率。总的来说，我们的结果支持了青光眼全脑结构重组的假设，该结构特定于结构连通性，可能将这种疾病归入了最近定义的一组大脑断开综合征。

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