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首页> 外文会议>Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Assessment of Objectively Measured Physical Activity as an Independent Estimator of Functional Status in Clinical Trials
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Assessment of Objectively Measured Physical Activity as an Independent Estimator of Functional Status in Clinical Trials

机译：客观测量身体活动的评估，作为临床试验中功能状态的独立评估者

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Functional status of patients is an important concept in clinical trials. It subsumes functional capacity, which is traditionally estimated by exercise tests, and functional performance, which is often estimated by questionnaires. Objectively measured physical activity by means of wearables devices containing accelerometers (PA) have recently been proposed as a novel and advantageous way to estimate physical status including capacity and performance. There is nonetheless insufficient evidence of the association between PA and traditional ways to estimate functional status. In the ACTIVATE clinical trial, cycle ergometry tests were performed multiple times in all 267 patients, PA was measured for a week prior to each cycle ergometry test, and questionnaires were answered daily during the same week. Pearson’s correlation tests and clustering analysis revealed that PA, physical activity experience as assessed by questionnaires, and exercise endurance time as measured by the cycle ergometry test, are largely independent. Therefore, all three approaches together might achieve a complete assessment of the functional status of patients in clinical trials, as they each independently correlate with health-related quality of life and important clinical outcomes such as hospitalizations but are weakly associated among themselves.
机译：患者的功能状态是临床试验中的重要概念。它载有功能容量，传统上通过运动测试和功能性能估计，通常由问卷调查估计。客观地通过含有加速度计（PA）的可穿戴物装置（PA）的物理活性的物理活性被提出为估计包括容量和性能的物理状态的新颖和有利的方式。尽管如此，PA与传统方式估计功能状况之间的关联证据不足。在激活临床试验中，在所有267名患者中多次进行循环钻石试验，在每个循环中测定术前测量PA一周，并在同一周内每天回答问卷。 Pearson的相关性测试和聚类分析显示PA，由问卷评估的PA，身体活动经验，并通过循环计力测试测量的锻炼耐力时间在很大程度上是独立的。因此，所有三种方法都可以实现对临床试验中患者功能状态的完全评估，因为它们各自与健康相关的生活质量和重要的临床结果（如住院等重要的临床结果）进行独立关联，而是在他们自己之间弱相关。

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