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首页> 外文会议>Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Disrupted Coupling Between NAA and Functional Connectivity in Ventromedial Prefrontal Cortex of Drug-Naïve First-Episode Psychosis
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Disrupted Coupling Between NAA and Functional Connectivity in Ventromedial Prefrontal Cortex of Drug-Naïve First-Episode Psychosis

机译：幼稚的首次发作性精神病的前内侧前额叶皮层中NAA和功能连接性之间的干扰耦合

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Ventromedial prefrontal cortex (vmPFC) is an important brain region involved in many psychological functions. Previous neuroimaging studies have shown disrupted function and altered metabolic level within vmPFC of schizophrenia (SCZ) patients. However, the linkage between the functional connectivity and its underlying neurobiological mechanism in SCZ remains unclear. In this study, we aimed to investigate the altered relationship between the functional connectivity strength (FCS) and metabolic concentrations within vmPFC in drug-naïve first-episode psychosis (FEP) patients using a combined functional magnetic resonance imaging (fMRI) and single-voxel proton magnetic resonance spectroscopy (1H- MRS) technique. There were 26 drug-naïve FEP patients and 27 matched healthy controls participated this study. We have found altered correlation between FCS and N-acetylaspartate (NAA) in drug-naïve FEP patients. In addition, the glutamate and glutamine compounds (Glx) and NAA concentrations were positively correlated with Positive and Negative Symptoms Scale (PANSS) total scores. Our findings revealed the disrupted functional-metabolic coupling within vmPFC in drug-naïve FEP patients and provided useful insights in understanding the etiology of SCZ.
机译：前内侧前额叶皮质（vmPFC）是涉及许多心理功能的重要大脑区域。先前的神经影像学研究表明，精神分裂症（SCZ）患者的vmPFC内功能受损，代谢水平改变。但是，功能连接性及其在SCZ中潜在的神经生物学机制之间的联系仍不清楚。在这项研究中，我们旨在研究功能性磁共振成像（fMRI）和单体素的结合，研究未使用过药物的首发精神病（FEP）患者中vmPFC中功能连接强度（FCS）与代谢浓度之间的变化关系。质子磁共振波谱学 1 H-MRS）技术。有26名未接受过药物治疗的FEP患者和27名相匹配的健康对照参加了这项研究。我们发现未使用过药物的FEP患者中FCS和N-乙酰天门冬氨酸（NAA）之间的相关性发生了变化。此外，谷氨酸和谷氨酰胺化合物（Glx）和NAA的浓度与阳性和阴性症状量表（PANSS）的总得分呈正相关。我们的发现揭示了初次使用FEP的vmPFC中功能代谢耦合的破坏，并为理解SCZ的病因提供了有用的见解。

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