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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Neurochemical and brain functional changes in the ventromedial prefrontal cortex of first-episode psychosis patients: A combined functional magnetic resonance imaging-proton magnetic resonance spectroscopy study
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Neurochemical and brain functional changes in the ventromedial prefrontal cortex of first-episode psychosis patients: A combined functional magnetic resonance imaging-proton magnetic resonance spectroscopy study

机译：第一发作精神病患者口腔前期皮质皮质的神经化学和脑功能变化：组合功能磁共振成像 - 质子磁共振光谱研究

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摘要

Objective: Previous studies showed alterations of brain function in the ventromedial prefrontal cortex of schizophrenia patients. Also, neurochemical changes, especially GABA level alteration, have been found in the medial prefrontal cortex of schizophrenia patients. However, the relationship between GABA level in the ventromedial prefrontal cortex and brain functional activity in schizophrenia patients remains unexplored. Methods: In total, 23 drug-naive, first-episode psychosis patients and 26 matched healthy controls completed the study. The single voxel proton magnetic resonance spectroscopy data were acquired in ventromedial prefrontal cortex region, which was used as the seed region for resting-state functional connectivity analysis. The proton magnetic resonance spectroscopy data were processed to quantify the concentrations of GABA+, glutamine and glutamate, and N-acetylaspartate in ventromedial prefrontal cortex. Spearman correlation analysis was used to examine the relationship between metabolite concentration, functional connectivity and clinical variables. Pearson correlation analysis was used to examine the relationship between GABA+ concentration and functional connectivity value. Results: In first-episode psychosis patients, GABA+ level in ventromedial prefrontal cortex was higher and was positively correlated with ventromedial prefrontal cortex-left middle orbital frontal cortex functional connectivity. N-acetylaspartate level was positively correlated with positive symptoms, and the functional connectivity between ventromedial prefrontal cortex and left precuneus was negatively associated with negative symptoms of first-episode psychosis patients. Conclusion: Our results indicated that ventromedial prefrontal cortex functional connectivity changes were positively correlated with higher local GABA+ level in first-episode psychosis patients. The altered neurochemical concentration and functional connectivity provide insights into the pathology of schizophrenia.
机译：目的：以前的研究表明精神分裂症患者口腔前期皮质脑功能的改变。此外，在精神分裂症患者的内侧前额叶皮质中发现了神经化学变化，特别是GABA水平改变。然而，精神分裂症患者口腔前期皮质皮层和脑功能活性的GABA水平之间的关系仍未开发。方法：总共23例药物 - 幼稚，第一集发作患者和26例匹配的健康对照完成了这项研究。在口腔前额叶皮质区域中获得单个体素质子磁共振光谱数据，其用作静态功能连接分析的种子区域。加工质子磁共振光谱数据以量化GABA +，谷氨酰胺和谷氨酸的浓度，介口前额叶皮质中的N-乙酰刺。 Spearman相关性分析用于检查代谢物浓度，功能性连体和临床变量之间的关系。 Pearson相关性分析用于检查GABA +浓度与功能连通值之间的关系。结果：在第一集发作精神病患者中，口腔前额叶皮质的GABA +水平较高，与腹侧前额叶皮质左中间眶正面皮质官能连接呈正相关。 N-乙酰刺酸盐水平与阳性症状正相关，腹侧前额叶皮质和左侧前梗塞之间的功能连通性与第一发作精神病患者的阴性症状负相关。结论：我们的研究结果表明，介文前额叶官能性连接变化与第一集精神病患者的较高局部GABA +水平正相关。改变的神经化学浓度和功能连接提供了精神分裂症病理的见解。

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  • 作者

    Cen Haixin; Xu Jiale; Yang Zhilei; Mei Li; Chen Tianyi; Zhuo Kaiming; Xiang Qiong; Song Zhenghua; Wang Yingchan; Guo Xiaoyun; Wang Jinhong; Jiang Kaida; Xu Yifeng; Li Yao; Liu Dengtang;

  • 作者单位

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Sch Biomed Engn Inst Med Imaging Technol 1954 Huashan Rd Shanghai;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Dept Med Imaging Sch Med Shanghai Peoples R;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Sch Biomed Engn Inst Med Imaging Technol 1954 Huashan Rd Shanghai;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    First-episode psychosis; ventromedial prefrontal cortex; neuronal metabolites; GABA; resting-state functional connectivity;

    机译：第一集精神病;腹侧前额叶皮质;神经元代谢物;GABA;休息状态功能连接;

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