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首页> 外文会议>5th International Photodynamic Association Biennial Meeting >Photodynamic therapy of the atherosclerotic abdominal aorta by laparoscopical a
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Photodynamic therapy of the atherosclerotic abdominal aorta by laparoscopical a

机译：腹腔镜下光动力疗法治疗腹主动脉粥样硬化

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Abstract: A new photosensitizer, PH-1126, was administered intravenously into the ear vein of cholesterol-fed atherosclerotic rabbits at a dose of 1 mg/kg of body weight. At 24 hours after PH-1126 administration, the atherosclerotic lesions of the abdominal aorta were irradiated by krypton ion laser at 647 nm of wavelength with 100 J/cm$+2$/. The abdominal aorta irradiated by laser beam was excised for histological analysis using the scanning electron microscopy and transmission electron microscopy. In the atherosclerotic plaque irradiated by krypton ion laser, migratory cells were observed and some of these cells were migrated into the lumen of the vessel. These findings suggested that these migratory cells from atherosclerotic plaque were foam cells destroyed by photodynamic therapy. !14
机译：摘要：将一种新的光敏剂PH-1126以1 mg / kg体重的剂量静脉内注射到胆固醇喂养的动脉粥样硬化兔的耳静脉中。在施用PH-1126后24小时，用k离子激光在波长647 nm处用100 J / cm $ + 2 $ /辐照腹主动脉的动脉粥样硬化病变。切除用激光束照射的腹主动脉，以使用扫描电子显微镜和透射电子显微镜进行组织学分析。在k离子激光照射的动脉粥样硬化斑块中，观察到迁移细胞，并且这些细胞中的一些迁移到血管腔中。这些发现表明，这些来自动脉粥样硬化斑块的迁移细胞是被光动力疗法破坏的泡沫细胞。 ！14

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