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GaAs/AlGaAs-based Mach-Zehnder interferometer as integrated optical immunosensor

机译:基于GaAs / AlGaAs的Mach-Zehnder干涉仪作为集成光学免疫传感器

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Abstract: System miniaturization is a key issue in further development of integrated optical sensors. We present an integrated optical GaAs/AlGaAs-based Mach-Zehnder interferometer with a 2 mm long TiO$-2$/ on SiO$-2$/ embedded waveguide sensor pad and its performance as a bioaffinity sensor. Preliminary experiments to evaluate the performance of our Mach-Zehnder interferometer device were done by studying the binding of immunoglobulin (IgG) to protein A. The current resolution limit of IgG surface coverage is 3 pg/mm$+2$/, corresponding to less than 1/1600 of a saturated IgG monolayer. Since the design of the basic GaAs/AlGaAs waveguide structure is fully compatible with monolithic integration of lasers, modulators and detectors, improved performance can be expected from integration of these optoelectronic components on the same chip. !21
机译:摘要:系统小型化是集成光学传感器进一步发展的关键问题。我们提出了一种集成的基于GaAs / AlGaAs的光学Mach-Zehnder干涉仪,其在SiO $ -2 $ /嵌入式波导传感器垫上具有2 mm长的TiO $ -2 $ /,并具有生物亲和力传感器的性能。通过研究免疫球蛋白(IgG)与蛋白A的结合进行了评估我们的Mach-Zehnder干涉仪设备性能的初步实验。IgG表面覆盖率的当前分辨率极限为3 pg / mm $ + 2 $ /,对应于比饱和IgG单层的1/1600倍。由于基本的GaAs / AlGaAs波导结构的设计与激光器,调制器和检测器的单片集成完全兼容,因此可以将这些光电组件集成在同一芯片上,从而提高性能。 !21

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