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Biological sensor based on localized surface plasmon associated with surface-bound Au/polystyrene composite microparticles

机译:基于与表面结合的Au /聚苯乙烯复合微粒相关的局部表面等离子体激元的生物传感器

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Abstract: We describe here a simple method for forming uniform surface-bound Au particles by using as a template monodisperse polystyrene spheres with diameters in the range of 100 to 350 nm; a dense submonolayer of the sphere was first formed on a substrate, followed by evaporation of Au. Cap-shaped Au particles were formed on the top half of the sphere. The particles exhibited strong optical absorption in the UV - near IR range whose peak position depended on the refractive index of the immediate environment. We show how the particle can be patterned on a substrate as well as modified with biomolecules in anticipation of incorporating the particles as a miniature biological sensor into micro analytical devices.!6
机译:摘要:我们在此描述一种简单的方法,该方法通过使用直径在100至350 nm范围内的单分散聚苯乙烯球体作为模板来形成均匀的表面结合金颗粒。首先在基底上形成致密的球单层,然后蒸镀金。在球形的上半部形成帽状的金颗粒。颗粒在UV-接近IR范围内表现出强烈的光吸收,其峰值位置取决于周围环境的折射率。我们展示了如何将颗粒图案化在基材上以及如何用生物分子修饰颗粒,从而有望将颗粒作为微型生物传感器并入微分析装置中!6

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