Biovector~(TM) loaded with a trivalent split influenza vaccine administered intranasally induce a strong mucosal and seric response in mice

机译：鼻内给予三价裂解流感疫苗的BiovectorTM在小鼠中引起强烈的粘膜和浆液反应

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Virus-like nanoparticles made of an inner core of a polysaccharidic hydrogel surrounded by a lipid bilayer (Fig. 1) and called SMBV for SupraMolecular Biovector~(TM) were developed. These nanoparticles mimicked flu viruses in terms of size (60nm) and supramolecular composition as they have a lipid bilayer (Fig. 1) where membranar proteins may be inserted and an internal core where internal proteins may be loaded.

机译：开发了由类脂质双层包围的多糖水凝胶内核组成的病毒样纳米颗粒（图1），并称为SupraMolecular BiovectorTM的SMBV。这些纳米粒子在大小（60nm）和超分子组成方面模仿了流感病毒，因为它们具有脂质双层（图1），膜中的蛋白质可以插入其中，内部核心可以装载内部的蛋白质。

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《International symposium on controlled release of bioactive materials;Consumer and diversified products conference》|1998年|p.643-644|共2页
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M. Major; R. Kravtzoff; I. De Miguel; T. Mabrouk; M. Laliberte; A. Etienne; D. Betbeder;
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1. Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4(+) cells and strong mucosal and systemic antibody responses in mice [J] . Madhun Abdullah S., Haaheim Lars R., Nostbakken Jane Kristin, Vaccine . 2011,第31期

机译：鼻内c-di-GMP佐剂植物源H5流感疫苗可诱导小鼠多功能Th1 CD4（+）细胞以及强烈的粘膜和全身抗体反应
2. Intranasal vaccination of recombinant H5N1 HA1 proteins fused with foldon and Fc induces strong mucosal immune responses with neutralizing activity: Implication for developing novel mucosal influenza vaccines [J] . Yu Fei, Li Ye, Guo Yan, Human vaccines & immunotherapeutics. . 2015,第12期

机译：融合有foldon和Fc的重组H5N1 HA1蛋白的鼻内疫苗接种可诱导具有中和活性的强粘膜免疫反应：对开发新型粘膜流感疫苗的意义
3. Intranasally administered Endocine (TM) formulated 2009 pandemic influenza H1N1 vaccine induces broad specific antibody responses and confers protection in ferrets [J] . Maltais Anna-Karin, Stittelaar Koert J., Kroeze Edwin J. B. Veldhuis, Vaccine . 2014,第26期

机译：鼻内给药的Endocine（TM）配制的2009年大流行性流感H1N1疫苗可诱导广泛的特异性抗体反应并赋予雪貂保护
4. Biovector~(TM) loaded with a trivalent split influenza vaccine administered intranasally induce a strong mucosal and seric response in mice. [C] . M. Major, R. Kravtzoff, I. De Miguel, International symposium on controlled release of bioactive materials . 1998

机译：含有三价分裂流感疫苗的Biovector〜（TM）鼻内施用，诱导小鼠的强粘膜和丝状反应。
5. The Administration of Intranasal Live Attenuated Influenza Vaccine Induces Changes in the Nasal Microbiota and Nasal Epithelium Gene Expression Profile. [D] . Tarabichi, Yasir. 2015

机译：鼻内减毒活疫苗的使用诱导鼻微生物群和鼻上皮基因表达谱的变化。
6. Intranasal vaccination of recombinant H5N1 HA1 proteins fused with foldon and Fc induces strong mucosal immune responses with neutralizing activity: Implication for developing novel mucosal influenza vaccines [O] . Fei Yu, Ye Li, Yan Guo, 2015

机译：重组H5N1 HA1蛋白与foldon和Fc融合后的鼻内疫苗接种可诱导具有中和活性的强粘膜免疫反应：对开发新型粘膜流感疫苗的意义
7. Intranasal Immunization of Mice with Influenza Vaccine in Combination with the Adjuvant LT-R72 Induces Potent Mucosal and Serum Immunity Which Is Stronger than That with Traditional Intramuscular Immunization [O] . J. D. Barackman, G. Ott, D. T. O’Hagan 1999

机译：用流感疫苗与佐剂LT-R72相结合的小鼠鼻内免疫诱导强粘膜和血清免疫，其与传统的肌肉注射免疫

Biovector~(TM) loaded with a trivalent split influenza vaccine administered intranasally induce a strong mucosal and seric response in mice

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