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首页> 外文期刊>Vaccine >Intranasally administered Endocine (TM) formulated 2009 pandemic influenza H1N1 vaccine induces broad specific antibody responses and confers protection in ferrets
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Intranasally administered Endocine (TM) formulated 2009 pandemic influenza H1N1 vaccine induces broad specific antibody responses and confers protection in ferrets

机译：鼻内给药的Endocine（TM）配制的2009年大流行性流感H1N1疫苗可诱导广泛的特异性抗体反应并赋予雪貂保护

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Influenza is a contagious respiratory disease caused by an influenza virus. Due to continuous antigenic drift of seasonal influenza viruses, influenza vaccines need to be adjusted before every influenza season. This allows annual vaccination with multivalent seasonal influenza vaccines, recommended especially for high-risk groups. There is a need for a seasonal influenza vaccine that induces broader and longer lasting protection upon easy administration. Endocine (TM) is a lipid-based mucosal adjuvant composed of endogenous lipids found ubiquitously in the human body. Intranasal administration of influenza antigens mixed with this adjuvant has been shown to induce local and systemic immunity as well as protective efficacy against homologous influenza virus challenge in mice. Here we used ferrets, an established animal model for human influenza virus infections, to further investigate the potential of Endocine (TM) as an adjuvant. Intranasal administration of inactivated pandemic H1N1/California/2009 split antigen or whole virus antigen mixed with Endocine (TM) induced high levels of serum hemagglutination inhibition (HI) and virus neutralization (VN) antibody titers that were also cross reactive against distant swine viruses of the same subtype. HI and VN antibody titers were already demonstrated after a single nasal immunization. Upon intratracheal challenge with a homologous challenge virus (influenza virus H1N1/The Netherlands/602/2009) immunized ferrets were fully protected from virus replication in the lungs and largely protected against body weight loss, virus replication in the upper respiratory tract and pathological changes in the respiratory tract. Endocine (TM) formulated vaccines containing split antigen induced higher HI and VN antibody responses and better protection from body weight loss and virus shedding in the upper respiratory tract than the Endocine (TM) formulated vaccine containing whole virus antigen
机译：流感是由流感病毒引起的传染性呼吸道疾病。由于季节性流感病毒的抗原持续漂移，需要在每个流感季节之前对流感疫苗进行调整。这样可以每年接种多价季节性流感疫苗，特别推荐用于高风险人群。需要一种季节性流感疫苗，该疫苗在易于施用时可诱导更广泛和更持久的保护。 Endocine（TM）是一种基于脂质的粘膜佐剂，由人体中普遍存在的内源性脂质组成。经鼻内注射与这种佐剂混合的流感抗原已显示出诱导小鼠局部免疫和全身免疫以及抵抗同源流感病毒攻击的保护功效。在这里，我们使用雪貂（一种建立的人类流感病毒感染动物模型）进一步研究Endocine（TM）作为佐剂的潜力。鼻内施用灭活的大流行H1N1 /加利福尼亚/ 2009分裂抗原或全病毒抗原与Endocine（TM）混合可诱导高水平的血清血凝抑制（HI）和病毒中和（VN）抗体滴度，这些抗体滴度也可与远处的猪病毒交叉反应相同的子类型。 HI和VN抗体滴度已在单次鼻腔免疫后得到证实。在气管内用同源攻击病毒（H1N1 /荷兰/ 602/2009流感病毒）攻击后，免疫的雪貂得到了充分的保护，使其免受肺部病毒复制，并在很大程度上减轻了体重，上呼吸道病毒的复制和病理变化。呼吸道。与包含完整病毒抗原的Endocine（TM）配制疫苗相比，包含分裂抗原的Endocine（TM）配制疫苗诱导更高的HI和VN抗体反应，并更好地防止体重减轻和上呼吸道病毒脱落

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