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Investigation and modelling of the structure of solid lipid nanoparticles

机译：固体脂质纳米颗粒结构的研究与建模

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During the last years increasing attention has been paid on lipid delivery systems as alternatives to polymeric nano-and microparticles. Their advantages are the low in vitro and in vivo cytotoxicity due to their physiological nature, the possibility of incorporating drugs for a prolonged release and the potential of large scale production by high pressure homogenisation (1). The solid lipid matrix offers the possibility to protect sensitive drugs from decomposition. Limited data are reported about structure and crystallinity of loaded solid lipid nanoparticles (SLN) (2,3). The physical structure influences stability, amount of incorporated drug and drug release. The aim of this study is the investigation of the inner structure of SLN loaded with the model drug chlorampenicol. Furthermore the modelling of inner structure will help to understand the incorporation of the drugs into the lipid.
机译：在过去的几年中，作为聚合物纳米和微粒的替代品，脂质输送系统受到了越来越多的关注。它们的优点是由于其生理特性而具有较低的体外和体内细胞毒性，可以掺入药物以延长释放的可能性以及通过高压均质化大规模生产的潜力（1）。固体脂质基质提供了保护敏感药物免于分解的可能性。关于装载的固体脂质纳米颗粒（SLN）的结构和结晶度报道的数据有限（2,3）。物理结构影响稳定性，掺入的药物量和药物释放。这项研究的目的是调查模型药物氯霉素对SLN的内部结构的研究。此外，内部结构的建模将有助于理解药物掺入脂质的过程。

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