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The process of obtaining solid lipid nanoparticles containing solid lipid nanoparticles containing curcuminoides curcuminoides, and use of the same
The process of obtaining solid lipid nanoparticles containing solid lipid nanoparticles containing curcuminoides curcuminoides, and use of the same
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机译：获得含有含有姜黄素的固体脂质纳米颗粒的固体脂质纳米颗粒的方法及其用途
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摘要
The process of obtaining solid lipid nanoparticles containing solid lipid nanoparticles containing curcuminoides curcuminoides, and use of the same.The present invention relates to the production process of solid lipid nanoparticles (NLS) containing curcurninoides as active principle and use thereof in the preparation of topical formulations for the prevention and treatment of radiodermite and other diseases of the skin.The NLS obtained in the example of implementation of the invention were evaluated by the content of curcuminoides, size, zeta potential, index of polidispersividade (PD (I), morphology, loading.And efficiency of encapsulation and the capacity of the topical formulations containing the NLS incorporated were evaluated for their physicochemical stability and biological, its permeation and penetration in vitro; your profile of in vitro release; the profile of its permeation and penetration in Alive,Anti inflammatory activity in vivo; clinical trials with patients in radiotherapic treatment and other diseases of the skin.
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