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首页> 外文会议>International symposium on controlled release of bioactive materials;Consumer and diversified products conference >Microencapsulated lipid cores for peptide colonic delivery
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Microencapsulated lipid cores for peptide colonic delivery

机译：微囊化脂质核心，可用于肽段结肠递送

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Lipid-based formulations such as micro-, nano- or multiple emulsions, nanocapsules or mixed micelles solutions, as well as the use of lipoidal adjuvants have bene shown promising in achieving both protection against degradation and enhanced absorption of peptide drugs at the intesinal wall~1-3. In fact, lipid substances such as unsaturated fatty acids or monoglycerides are considered one of the most effective class of absorption enhancers, and have been shown to alter the permeability of different mucosal membranes. Triglycerides and other fatty acid derivatives are generally considered to possess a more important role as protective vehicles against enzymatic degradation, although its is also expected that they form, by lipolysis, substances with a transient enhancing effect~4.
机译：基于脂质的制剂，例如微，纳米或多种乳剂，纳米胶囊或混合的胶束溶液，以及使用脂质佐剂，显示出有望实现在肠壁上防止肽类药物降解和增强吸收的效果。 1-3。实际上，脂类物质（例如不饱和脂肪酸或甘油单酸酯）被认为是最有效的吸收促进剂之一，并且已显示出可以改变不同粘膜的通透性。甘油三酸酯和其他脂肪酸衍生物通常被认为在抵抗酶促降解方面起着更重要的作用，尽管人们也期望甘油三酸酯通过脂解作用形成具有瞬时增强作用的物质[4]。

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