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Microencapsulated lipid cores for peptide colonic delivery

机译：用于肽结肠递送的微胶囊化脂质芯

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Lipid-based formulations such as micro-, nano- or multiple emulsions, nanocapsules or mixed micelles solutions, as well as the use of lipoidal adjuvants have bene shown promising in achieving both protection against degradation and enhanced absorption of peptide drugs at the intesinal wall~1-3. In fact, lipid substances such as unsaturated fatty acids or monoglycerides are considered one of the most effective class of absorption enhancers, and have been shown to alter the permeability of different mucosal membranes. Triglycerides and other fatty acid derivatives are generally considered to possess a more important role as protective vehicles against enzymatic degradation, although its is also expected that they form, by lipolysis, substances with a transient enhancing effect~4.
机译：脂质的制剂如微型，纳米或多种乳液，纳米胶囊或混合胶束溶液以及脂肪型辅助剂的使用具有BENE，在实现防止抗体和增强肽药物在interneL壁上的肽药物〜 1-3。事实上，脂质物质如不饱和脂肪酸或多甘油酯被认为是最有效的吸收增强剂之一，并且已经显示出改变不同粘膜的渗透性。甘油三酯和其他脂肪酸衍生物通常认为具有更重要的作用作为防止酶促降解的保护型，尽管它们也预期通过脂解，瞬态增强作用的物质形成〜4。

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