Multipulse permeation through a membrane driven by a chemical pH oscillator

机译：通过化学pH振荡器驱动的膜的多脉冲渗透

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Interest in periodic, pulsing drug release has increased in recent years due to the need to produce systems for the replacement of hormones which are released endogenously in periodic pulses, for certain cancer chemotherapies, and for drugs that exhibit tolerance. To this end the use of chemical pH-oscillator has been explored, with the idea that an oscillating pH leads to oscillations in permeability of weak acidic or basic drugs across lipophilic membranes.~1

机译：近年来，由于需要生产用于代替周期性脉冲内源性释放的激素，用于某些癌症化学疗法以及表现出耐受性的药物的系统，因此对周期性脉冲药物的关注日益增加。为此，已经探索了使用化学pH振荡器的想法，认为pH的振荡会导致弱酸性或碱性药物在亲脂膜上的渗透性振荡。〜1

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《International symposium on controlled release of bioactive materials;Consumer and diversified products conference》|2000年|p.774-775|共2页
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Gauri P.Misra; Ronald A.Siegel;
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中图分类基础医学;
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1. Multipulse drug permeation across a membrane driven by a chemical pH-oscillator [J] . Misra GP., Siegel RA. Journal of Controlled Release: Official Journal of the Controlled Release Society . 2002,第1a3期

机译：由化学pH振荡器驱动的跨膜的多脉冲药物渗透
2. Reverse permeation of sodium ions driven by pH difference across a liquid membrane: time dependencies of membrane resistance and membrane potential in a reverse permeation system [J] . Kazuo Nomura Journal of Membrane Science . 1996,第2期

机译：pH值跨液膜驱动的钠离子的反渗透：反渗透系统中膜电阻和膜电位的时间依赖性
3. Hydrogen permeance and the effect of H2O and CO on the permeability of Pd_(0.75)Ag_(0.25) membranes under gas-driven permeation and plasma-driven permeation [J] . Thu Hoai Nguyen, Shinsuke Mori, Masaaki Suzuki Chemical engineering journal . 2009,第1a2期

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4. Multipulse permeation through a membrane driven by a chemical pH oscillator [C] . Gauri P.Misra, Ronald A.Siegel International symposium on controlled release of bioactive materials . 2000

机译：通过化学pH振荡器驱动的膜的多集水渗透
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Multipulse permeation through a membrane driven by a chemical pH oscillator

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