PHARMACOKINETICS OF CIPROFLOXACIN GASTRIC RETENTIVE (GR~(TM)) TABLETS IN HEALTHY VOLUNTEERS

机译：保健志愿者中环丙沙星胃药保留片（GR〜（TM））的药代动力学

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

SUMMARY The pharmacokinetics of 2 formulations of gastric retentive tablets of ciprofloxacin hydrochloride and the immediate release tablet (Cipro~(~R) 500 mg base) were compared in 15 healthy volunteers. Retention in the stomach in the fed mode was based on polymeric swelling, and drug release was based on polymeric erosion. Extended release profiles were observed for the gastric retentive tablets with comparable bioavailability to the immediate release tablet.

机译：总结在15位健康志愿者中比较了2种盐酸盐环丙沙星胃滞留片和速释片（Cipro〜R 500 mg碱）的药代动力学。进食模式下胃中的滞留是基于聚合物溶胀，药物释放是基于聚合物溶蚀。观察到具有与速释片剂相当的生物利用度的胃滞留片剂的缓释曲线。

著录项

来源
《International symposium on controlled release of bioactive materials;Consumer diversified products conference》|2001年|p.698-699|共2页
会议地点
作者
J. Louie-Helm; R. Fell; J.N. Shell; D. Dye; G. Levy; J. Gorsline; M. Mueller; C. Dilger; B. Berner;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类基础医学;
关键词
oral drug delivery; single-unit dosage forms; hydrogels; drug absorption;

机译：口服药物递送;单单位剂型;水凝胶药物吸收;

相似文献

外文文献
中文文献
专利

1. Pharmacokinetics of metformin gastric-retentive tablets in healthy volunteers. [J] . Gusler G, Gorsline J, Levy G, The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2001,第6期

机译：二甲双胍胃滞留片在健康志愿者中的药代动力学。
2. Pharmacokinetics of gabapentin after a single day and at steady state following the administration of gastric-retentive- extended-release and immediate-release tablets: A randomized, open-label, multiple-dose, three-way crossover, exploratory study in healthy subjects. [J] . Gordi T, Hou E, Kasichayanula S, Clinical therapeutics . 2008,第5期

机译：加巴喷丁在服用胃滞留性缓释和速释片剂后的第一天并处于稳定状态的药代动力学：在健康受试者中进行的一项随机，开放标签，多剂量，三向交叉，探索性研究。
3. Pharmacokinetics and bioequivalence evaluation of two brands of ciprofloxacin 500mg tablets in Iranian healthy volunteers [J] . Arzneimittel-Forschung: =Drug Research . 2012,第12期

机译：两个品牌的环丙沙星500mg片剂在伊朗健康志愿者中的药代动力学和生物等效性评估
4. Single- Dose Pharmacokinetics of Gabapentin Gastric Retentive (GR?) Tablets in Healthy Volunteers [C] . Controlled Release Society annual meeting . 2004

机译：胃肠杆菌胃保留（GRα）平板电脑的单剂量药代动力学在健康志愿者中
5. Hydrophilic polymer viscosities on gastric retentive drug delivery systems of Gabapentin sustained release tablets [D] . Johns, Benjamin Onnoonay 2010

机译：加巴喷丁缓释片在胃滞留给药系统上的亲水性聚合物粘度
6. Statistical optimization of a novel excipient (CMEC) based gastro retentive floating tablets of propranolol HCl and it’s in vivo buoyancy characterization in healthy human volunteers [O] . Venkata Srikanth Meka, Sreenivasa Rao Nali, Ambedkar Sunil Songa, 2012

机译：统计优化基于普萘洛尔盐酸盐的新型赋形剂（CMEC）的胃滞留漂浮片及其对健康人类志愿者的体内浮力特性
7. When Bioequivalence in Healthy Volunteers May not Translate to Bioequivalence in Patients: Differential Effects of Increased Gastric pH on the Pharmacokinetics of Levothyroxine Capsules and Tablets [O] . Corinne Seng Yue, Salvatore Benvenga, Claudia Scarsi, 2015

机译：当健康志愿者的生物等效可能不会转化为患者的生物等效性：胃pH增加的差异效果对左旋甲基胶囊和片剂的药代动力学

PHARMACOKINETICS OF CIPROFLOXACIN GASTRIC RETENTIVE (GR~(TM)) TABLETS IN HEALTHY VOLUNTEERS

摘要

著录项

相似文献

相关主题

期刊订阅