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首页> 外文会议>Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE >Time-varying analysis of autonomic control during arousal from sleep in obstructive sleep apnea syndrome
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Time-varying analysis of autonomic control during arousal from sleep in obstructive sleep apnea syndrome

机译：阻塞性睡眠呼吸暂停综合征觉醒期间自主控制的时变分析

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Patients with obstructive sleep apnea syndrome (OSAS) have elevated sympathetic drive and impaired parasympathetic cardiac control during wakefulness and sleep. Previous studies have demonstrated that sympathetic overactivity in OSAS can lead to impaired peripheral vasodilatory responses to hypoxia. The present study was conducted to determine whether the autonomic response to arousal from sleep is also altered in OSAS. In 8 OSAS and 8 normal controls, we performed time-varying spectral analyses of cardiovascular and respiratory variability following acoustically-induced arousal from sleep. In all subjects and in both REM and non-REM sleep, the arousal responses of the spectral parameters representing vagal heart-rate modulation were small or non-existent after accounting for the accompanying changes in respiration. In non-REM sleep, the OSAS subjects showed substantially attenuated cardiac sympathetic responses to arousal but the peripheral vascular response was preserved. In REM sleep, the sympathetic cardiovascular responses to arousal were similar in both subject groups, but these responses were much smaller than those exhibited by normals in non-REM sleep. Our results suggest that OSAS leads primarily to an impairment of the cardiac sympathoexcitatory reaction to arousal from non-REM sleep; however, the normal autonomic cardiovascular response to arousal in REM sleep appears to be preserved.
机译：阻塞性睡眠呼吸暂停综合症（OSAS）患者在清醒和睡眠期间的交感驱动力增强，而副交感神经控制受损。先前的研究表明，OSAS中的交感神经过度活动可导致对缺氧的外周血管舒张反应减弱。进行本研究以确定OSAS中是否也改变了对睡眠引起的自主反应。在8个OSAS和8个正常对照中，我们对听觉引起的睡眠唤醒进行了心血管和呼吸变异性的时变光谱分析。在所有受试者中，在REM和非REM睡眠中，考虑到伴随的呼吸变化，代表迷走性心率调节的频谱参数的唤醒反应很小或不存在。在非快速眼动睡眠中，OSAS受试者表现出明显的对唤醒的心脏交感反应，但周围血管反应得以保留。在快速眼动睡眠中，两个对象组对唤醒的交感性心血管反应相似，但是这些反应比非快速眼动睡眠中正常人的反应要小得多。我们的结果表明，OSAS主要导致心脏交感兴奋反应对非快速眼动睡眠引起的损害。然而，似乎可以保留正常的自主神经对快速眼动睡眠的唤醒反应。

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